Detailed information of TA system TA113078

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 177984..178206
• Replicon: chromosome
• Accession: NZ_CP033092
• Organism: Escherichia coli DSM 30083 = JCM 1649 = ATCC 11775

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: EAS44_RS01645
• Protein ID: WP_001295224.1
• Coordinates: 178099..178206 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	177984..178050 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EAS44_RS01620	173856..174839	+	984	WP_001196477.1	dipeptide ABC transporter ATP-binding protein	-
EAS44_RS01625	174836..175840	+	1005	WP_000103579.1	dipeptide ABC transporter ATP-binding subunit DppF	-
EAS44_RS01630	175870..177141	-	1272	WP_001332306.1	amino acid permease	-
EAS44_RS01640	177617..177724	+	108	WP_000170745.1	type I toxin-antitoxin system toxin Ldr family protein	-
-	177984..178050	-	67	-	-	Antitoxin
EAS44_RS01645	178099..178206	+	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
EAS44_RS01655	178582..178689	+	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	-
EAS44_RS01660	178775..180454	-	1680	WP_025857850.1	cellulose biosynthesis protein BcsG	-
EAS44_RS01665	180451..180642	-	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
EAS44_RS01670	180639..182210	-	1572	WP_001204957.1	cellulose biosynthesis protein BcsE	-
EAS44_RS01675	182483..182671	+	189	WP_001063314.1	YhjR family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T113078 WP_001295224.1 NZ_CP033092:178099-178206 [Escherichia coli DSM 30083 = JCM 1649 = ATCC 11775]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T113078 NZ_CP033092:178099-178206 [Escherichia coli DSM 30083 = JCM 1649 = ATCC 11775]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCACGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 67 bp

>AT113078 NZ_CP033092:c178050-177984 [Escherichia coli DSM 30083 = JCM 1649 = ATCC 11775]
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin