Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 115589..116450 Replicon plasmid pBTX_120
Accession NZ_CP033074
Organism Buttiauxella sp. 3AFRM03

Toxin (Protein)


Gene name yhaV Uniprot ID -
Locus tag D8682_RS00780 Protein ID WP_121813096.1
Coordinates 115956..116450 (+) Length 165 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID -
Locus tag D8682_RS00775 Protein ID WP_121813192.1
Coordinates 115589..115933 (+) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D8682_RS00735 112036..112482 + 447 WP_121813191.1 DUF1419 domain-containing protein -
D8682_RS00740 112554..112823 + 270 WP_121813089.1 hypothetical protein -
D8682_RS00745 112864..113235 + 372 WP_121813090.1 hypothetical protein -
D8682_RS00750 113228..113746 + 519 WP_121813091.1 hypothetical protein -
D8682_RS00755 113895..114176 + 282 WP_121813092.1 hypothetical protein -
D8682_RS00760 114282..114542 + 261 WP_121813093.1 DUF1380 family protein -
D8682_RS00765 114536..114763 + 228 WP_121813094.1 hypothetical protein -
D8682_RS00770 115017..115238 + 222 WP_121813095.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
D8682_RS00775 115589..115933 + 345 WP_121813192.1 type II toxin-antitoxin system PrlF family antitoxin Antitoxin
D8682_RS00780 115956..116450 + 495 WP_121813096.1 type II toxin-antitoxin system YhaV family toxin Toxin
D8682_RS00790 116958..117641 + 684 WP_121813098.1 hypothetical protein -
D8682_RS00795 117710..117925 + 216 WP_121813099.1 hypothetical protein -
D8682_RS00800 118043..118715 + 673 Protein_156 DUF4942 domain-containing protein -
D8682_RS00805 118776..119470 + 695 Protein_157 IS1 family transposase -
D8682_RS26915 119849..120313 + 465 WP_202914340.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..120955 120955
- flank IS/Tn - - 118776..118994 218


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(11-147)

Antitoxin

PrlF antitoxin

(16-114)


Sequences

Toxin        


Download         Length: 165 a.a.        Molecular weight: 19097.84 Da        Isoelectric Point: 8.4122

>T113046 WP_121813096.1 NZ_CP033074:115956-116450 [Buttiauxella sp. 3AFRM03]
MEYVELNGWKIFFHSCFLKQIAELTEKVVALKASKPNEYKGKKETKLLKAIERVIEERIATDPFNPQYRQGDTLGDEYKH
WFRAKFLSQFRLFYRCSDEYKTIIIGWVNDFDTLRAYGSKTDAYKVFSGMLKAGEPPEDWDTLLTQAKKATSTTSIPGFL
DNQI

Download         Length: 495 bp

>T113046 NZ_CP033074:115956-116450 [Buttiauxella sp. 3AFRM03]
ATGGAATACGTAGAGTTAAACGGGTGGAAAATCTTCTTTCATTCATGCTTTCTGAAGCAGATTGCAGAATTGACTGAGAA
GGTAGTGGCTTTAAAAGCTTCAAAGCCAAATGAATACAAAGGCAAGAAGGAAACCAAGCTCCTGAAGGCGATTGAGCGCG
TGATTGAGGAACGGATAGCAACCGATCCCTTCAATCCGCAATACCGTCAGGGAGATACGTTAGGCGATGAATATAAACAC
TGGTTCCGCGCCAAGTTTCTTTCGCAGTTCCGTTTGTTCTATCGTTGCAGCGATGAGTACAAAACTATCATTATCGGTTG
GGTTAACGATTTCGATACCCTACGCGCTTACGGCTCTAAAACGGACGCCTACAAGGTGTTTTCAGGGATGCTAAAGGCAG
GAGAGCCGCCTGAAGACTGGGATACACTTCTCACTCAGGCAAAGAAAGCCACTTCCACAACCTCTATTCCTGGTTTCCTC
GATAATCAAATCTAG

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 12796.53 Da        Isoelectric Point: 4.4227

>AT113046 WP_121813192.1 NZ_CP033074:115589-115933 [Buttiauxella sp. 3AFRM03]
MATQYLNSADVSLRAESRLTERSQTTIPAAIRDALHLKPGEYIKYTLMAGGKVIMSRQEEEQDDPVVSQFLTFLENDMKK
NPQNIHPVPVMFWDSMKALTAGVEVDLDAPLTDD

Download         Length: 345 bp

>AT113046 NZ_CP033074:115589-115933 [Buttiauxella sp. 3AFRM03]
ATGGCTACTCAATATTTAAACAGTGCGGATGTGTCACTGCGTGCTGAGTCTCGACTCACCGAACGCAGCCAGACAACGAT
CCCGGCAGCAATACGCGATGCCTTGCACCTCAAGCCTGGGGAGTACATTAAGTACACCTTGATGGCTGGCGGTAAAGTCA
TCATGTCCCGACAGGAAGAAGAACAGGACGACCCGGTTGTATCGCAGTTTCTGACTTTTCTCGAAAATGACATGAAGAAA
AACCCGCAGAACATTCACCCAGTACCGGTAATGTTTTGGGATAGCATGAAAGCACTGACTGCTGGAGTTGAGGTCGATTT
AGACGCGCCGCTTACCGATGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References