Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 5249411..5250067 Replicon chromosome
Accession NZ_CP033055
Organism Serratia sp. 3ACOL1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag D9980_RS23850 Protein ID WP_121608629.1
Coordinates 5249723..5250067 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag D9980_RS23845 Protein ID WP_121608628.1
Coordinates 5249411..5249701 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D9980_RS23820 5244821..5245549 - 729 WP_162304323.1 RES family NAD+ phosphorylase -
D9980_RS23825 5245530..5246291 - 762 WP_121608625.1 hypothetical protein -
D9980_RS23830 5246417..5247238 - 822 WP_121608626.1 helix-turn-helix transcriptional regulator -
D9980_RS23835 5247381..5248259 + 879 WP_121608627.1 helix-turn-helix domain-containing protein -
D9980_RS23840 5248438..5249358 + 921 WP_024485479.1 L,D-transpeptidase family protein -
D9980_RS23845 5249411..5249701 - 291 WP_121608628.1 helix-turn-helix domain-containing protein Antitoxin
D9980_RS23850 5249723..5250067 - 345 WP_121608629.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
D9980_RS23855 5250285..5251001 - 717 WP_071682471.1 GntR family transcriptional regulator -
D9980_RS23860 5251236..5253161 + 1926 WP_121608630.1 PTS 2-O-a-mannosyl-D-glycerate transporter subunit IIABC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(45-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-80)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13155.15 Da        Isoelectric Point: 9.5285

>T113020 WP_121608629.1 NZ_CP033055:c5250067-5249723 [Serratia sp. 3ACOL1]
MEYFEFIETPVFSRQRETLLDDDSFRELQTHLLKYHADGDTISKTGGCKKIRWNRPGMGKQGGVRVIYYVITRSGKVYLL
IVYPKNAKDDLTEAEKAILKALTDKLNYTVPHKA

Download         Length: 345 bp

>T113020 NZ_CP033055:c5250067-5249723 [Serratia sp. 3ACOL1]
ATGGAATACTTTGAGTTCATCGAAACCCCAGTTTTTAGCAGGCAACGCGAAACCCTATTAGACGATGATAGCTTTCGTGA
GCTACAAACCCACCTGTTAAAATATCACGCAGACGGCGATACTATAAGTAAAACAGGCGGTTGCAAAAAAATCCGATGGA
ACCGTCCAGGCATGGGGAAACAAGGTGGTGTAAGAGTTATCTATTACGTCATCACCCGCAGCGGCAAGGTTTACCTGTTG
ATTGTTTATCCTAAAAACGCCAAAGACGACTTAACCGAAGCCGAGAAAGCGATACTTAAAGCGTTAACCGATAAACTGAA
TTACACGGTGCCGCACAAGGCATAG

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10884.57 Da        Isoelectric Point: 6.4836

>AT113020 WP_121608628.1 NZ_CP033055:c5249701-5249411 [Serratia sp. 3ACOL1]
VDKELFNDLVESMEQMVAIEKGEMQPARVHRHHIPNVKSLREASGMKQEEFAQAVGVSPSLVQSWEQNRRIPSGSSLKIL
LMIERHPTIINDLLAI

Download         Length: 291 bp

>AT113020 NZ_CP033055:c5249701-5249411 [Serratia sp. 3ACOL1]
GTGGACAAAGAACTTTTTAACGATCTGGTCGAAAGCATGGAACAGATGGTCGCGATTGAAAAAGGCGAAATGCAGCCTGC
TCGTGTCCATCGCCATCATATCCCCAACGTGAAATCACTACGCGAAGCCAGCGGCATGAAGCAGGAAGAGTTTGCGCAGG
CGGTTGGAGTTAGTCCTTCCCTGGTGCAAAGTTGGGAACAAAATCGTCGAATACCCTCCGGCTCTTCACTCAAAATCTTG
CTGATGATTGAGCGCCACCCCACCATTATTAACGATCTACTCGCCATCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References