Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/MqsA(antitoxin)
Location 4432643..4433295 Replicon chromosome
Accession NZ_CP033055
Organism Serratia sp. 3ACOL1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag D9980_RS20005 Protein ID WP_121608252.1
Coordinates 4432643..4432984 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag D9980_RS20010 Protein ID WP_121608253.1
Coordinates 4432981..4433295 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D9980_RS19980 4427730..4428461 - 732 WP_024484696.1 phosphate signaling complex protein PhoU -
D9980_RS19985 4428474..4429250 - 777 WP_021181414.1 phosphate ABC transporter ATP-binding protein PstB -
D9980_RS19990 4429298..4430188 - 891 WP_024484695.1 phosphate ABC transporter permease PstA -
D9980_RS19995 4430190..4431146 - 957 WP_121608250.1 phosphate ABC transporter permease PstC -
D9980_RS20000 4431237..4432277 - 1041 WP_121608251.1 phosphate ABC transporter substrate-binding protein PstS -
D9980_RS20005 4432643..4432984 + 342 WP_121608252.1 toxin Toxin
D9980_RS20010 4432981..4433295 + 315 WP_121608253.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
D9980_RS20015 4433395..4434474 - 1080 WP_162304301.1 GNAT family N-acetyltransferase -
D9980_RS20020 4434476..4435594 - 1119 WP_121608255.1 carbamoyl-phosphate synthase large subunit -
D9980_RS20025 4435716..4437545 - 1830 WP_121608256.1 glutamine--fructose-6-phosphate transaminase (isomerizing) -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin MqsA/HigA-2

(29-99)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13445.64 Da        Isoelectric Point: 9.7267

>T113017 WP_121608252.1 NZ_CP033055:4432643-4432984 [Serratia sp. 3ACOL1]
MDAIFVELSIFEAKRADYLSDDEFKTFQQMLLINPFCGDVIQHTGGLRKVRFADHRRGKGKRGGLRVIYYWWLEKSHFLL
FVIYDKDKKDDLSRNEREMLRKMLEILKQGGTL

Download         Length: 342 bp

>T113017 NZ_CP033055:4432643-4432984 [Serratia sp. 3ACOL1]
ATGGATGCTATATTTGTTGAGTTAAGTATTTTTGAAGCGAAGCGTGCTGATTATCTTTCCGATGATGAATTCAAGACATT
CCAGCAGATGCTGCTTATTAATCCATTCTGCGGTGATGTTATCCAGCACACTGGCGGGTTAAGGAAGGTCAGATTTGCGG
ATCACCGTCGTGGAAAAGGTAAACGAGGTGGCTTGCGGGTGATCTATTATTGGTGGCTTGAAAAGTCTCACTTTTTGCTT
TTTGTCATTTACGACAAAGACAAAAAAGATGACCTTAGCCGCAACGAGCGCGAGATGCTGCGTAAGATGTTGGAAATTTT
GAAACAAGGGGGCACCTTATGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11884.72 Da        Isoelectric Point: 7.2018

>AT113017 WP_121608253.1 NZ_CP033055:4432981-4433295 [Serratia sp. 3ACOL1]
MSELSLFEELTQGMKDWSDYNEGKITLKTHAVSLKKNISMSPDELKAIREKLRLSQAVFADYLHTGVTTYQNWEQGRAKP
NKQALLLIRMVEKDPMTLDTLAAL

Download         Length: 315 bp

>AT113017 NZ_CP033055:4432981-4433295 [Serratia sp. 3ACOL1]
ATGAGCGAACTCAGCCTTTTTGAAGAACTGACCCAGGGAATGAAAGACTGGAGTGATTACAATGAGGGTAAAATCACGCT
TAAAACCCACGCCGTATCACTGAAAAAAAACATATCTATGTCACCAGACGAGTTAAAAGCAATACGTGAAAAACTGCGTC
TTTCACAAGCCGTTTTTGCGGATTACTTGCATACCGGTGTCACTACTTATCAAAACTGGGAGCAGGGCAGAGCCAAACCC
AACAAACAGGCACTTCTTTTGATCCGTATGGTTGAAAAAGACCCAATGACGCTCGATACGTTAGCTGCCTTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References