Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 725975..726668 Replicon chromosome
Accession NZ_CP033020
Organism Escherichia coli ATCC 8739

Toxin (Protein)


Gene name mqsR Uniprot ID -
Locus tag D9Q99_RS03525 Protein ID WP_000415583.1
Coordinates 725975..726271 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag D9Q99_RS03530 Protein ID WP_000650107.1
Coordinates 726273..726668 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D9Q99_RS03490 (721063) 721063..721377 - 315 WP_000958598.1 putative quinol monooxygenase -
D9Q99_RS03495 (721408) 721408..721989 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
D9Q99_RS03500 (722308) 722308..722640 + 333 WP_000917684.1 DUF2645 family protein -
D9Q99_RS03505 (722686) 722686..724035 - 1350 WP_000673401.1 quorum sensing histidine kinase QseC -
D9Q99_RS03510 (724032) 724032..724691 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
D9Q99_RS03515 (724843) 724843..725235 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
D9Q99_RS03520 (725288) 725288..725770 + 483 WP_000183505.1 GyrI-like domain-containing protein -
D9Q99_RS03525 (725975) 725975..726271 + 297 WP_000415583.1 type II toxin-antitoxin system toxin MqsR Toxin
D9Q99_RS03530 (726273) 726273..726668 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
D9Q99_RS03535 (726801) 726801..728408 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
D9Q99_RS03540 (728546) 728546..730804 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(2-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11216.99 Da        Isoelectric Point: 8.9070

>T112955 WP_000415583.1 NZ_CP033020:725975-726271 [Escherichia coli ATCC 8739]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGLV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T112955 NZ_CP033020:725975-726271 [Escherichia coli ATCC 8739]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCTGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT112955 WP_000650107.1 NZ_CP033020:726273-726668 [Escherichia coli ATCC 8739]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT112955 NZ_CP033020:726273-726668 [Escherichia coli ATCC 8739]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References