Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 5883225..5883780 Replicon chromosome
Accession NZ_CP033019
Organism Janthinobacterium agaricidamnosum strain BHSEK

Toxin (Protein)


Gene name yoeB Uniprot ID A0A853SUS2
Locus tag D9M09_RS26545 Protein ID WP_070223221.1
Coordinates 5883225..5883530 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2G3MIP6
Locus tag D9M09_RS26550 Protein ID WP_070223351.1
Coordinates 5883511..5883780 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D9M09_RS26520 5878903..5879241 + 339 WP_070223211.1 hypothetical protein -
D9M09_RS26525 5879334..5881490 + 2157 WP_121670750.1 TonB-dependent receptor -
D9M09_RS26530 5881592..5882074 - 483 WP_162995799.1 GNAT family N-acetyltransferase -
D9M09_RS26535 5882049..5882360 - 312 WP_071650246.1 DUF1778 domain-containing protein -
D9M09_RS26540 5882466..5883134 - 669 WP_070223219.1 uracil-DNA glycosylase -
D9M09_RS26545 5883225..5883530 - 306 WP_070223221.1 Txe/YoeB family addiction module toxin Toxin
D9M09_RS26550 5883511..5883780 - 270 WP_070223351.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
D9M09_RS26555 5883903..5884910 - 1008 WP_070312669.1 lipoyl synthase -
D9M09_RS26560 5884948..5885652 - 705 WP_070223225.1 lipoyl(octanoyl) transferase LipB -
D9M09_RS26565 5885728..5887200 - 1473 WP_121670752.1 PLP-dependent aminotransferase family protein -
D9M09_RS26570 5887326..5888597 + 1272 WP_121670753.1 multidrug effflux MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(19-98)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11869.50 Da        Isoelectric Point: 7.7710

>T112951 WP_070223221.1 NZ_CP033019:c5883530-5883225 [Janthinobacterium agaricidamnosum]
MKNRKTENKQQARAAVLAWTDHAWEDYLFWQENDLKILQKINDLLDACLADPFKGTGKPEPLKGDLTGFWSRRIDRQHRL
VYLPDAGCIYVAACRYHYDDK

Download         Length: 306 bp

>T112951 NZ_CP033019:c5883530-5883225 [Janthinobacterium agaricidamnosum]
ATGAAAAACCGGAAGACTGAAAACAAGCAGCAGGCGCGCGCCGCCGTGCTGGCCTGGACCGATCATGCCTGGGAGGATTA
TCTGTTCTGGCAAGAGAACGACTTGAAAATCCTGCAAAAAATCAACGACTTGCTCGATGCATGCCTGGCCGATCCGTTCA
AGGGCACGGGCAAGCCGGAACCGCTGAAAGGCGACCTGACGGGTTTCTGGTCGCGCCGCATCGACCGCCAGCACCGGCTC
GTGTATCTGCCCGACGCGGGCTGCATCTACGTGGCGGCCTGCCGTTATCACTATGACGACAAATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9741.12 Da        Isoelectric Point: 6.7153

>AT112951 WP_070223351.1 NZ_CP033019:c5883780-5883511 [Janthinobacterium agaricidamnosum]
MNILTFSEARAGLKSVMDDVCNDHTPTVITRVNGEHVVMLSLSDYNSIEETLYLLGTAKNASRLMASVAQIKAGKAQPRA
LARHEKPED

Download         Length: 270 bp

>AT112951 NZ_CP033019:c5883780-5883511 [Janthinobacterium agaricidamnosum]
ATGAATATCCTGACTTTCAGCGAGGCGCGCGCGGGCCTGAAAAGCGTGATGGACGACGTCTGCAACGACCATACGCCTAC
GGTGATCACGCGCGTGAATGGCGAACATGTGGTGATGCTGTCCTTGTCGGACTACAACAGCATCGAGGAAACCCTGTATT
TGCTGGGCACGGCAAAGAATGCCAGCCGGCTGATGGCGTCCGTGGCGCAGATCAAGGCGGGCAAGGCGCAGCCACGGGCA
TTGGCGCGGCATGAAAAACCGGAAGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853SUS2

Antitoxin

Source ID Structure
AlphaFold DB A0A2G3MIP6

References