Detailed information of TA system TA112831

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DinJ-YafQ (relBE)/YafQ(toxin)
• Location: 1561310..1561898
• Replicon: chromosome
• Accession: NZ_CP032909
• Organism: Helicobacter pylori strain 21-A-EK1

Toxin (Protein)

• Gene name: TfiT
• Uniprot ID: A0A496ESF5
• Locus tag: D4I01_RS07685
• Protein ID: WP_033756152.1
• Coordinates: 1561617..1561898 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: TfiA
• Uniprot ID: -
• Locus tag: D4I01_RS07680
• Protein ID: WP_139543530.1
• Coordinates: 1561310..1561624 (+)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D4I01_RS07660	1556846..1557511	+	666	WP_139543527.1	ParA family protein	-
D4I01_RS07665	1557585..1557869	+	285	WP_000394655.1	hypothetical protein	-
D4I01_RS07670	1557901..1559079	+	1179	WP_139543528.1	hypothetical protein	-
D4I01_RS07675	1559104..1561017	-	1914	WP_139543529.1	relaxase/mobilization nuclease domain-containing protein	-
D4I01_RS07680	1561310..1561624	+	315	WP_139543530.1	hypothetical protein	Antitoxin
D4I01_RS07685	1561617..1561898	+	282	WP_033756152.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
D4I01_RS07690	1562173..1563900	-	1728	WP_139545879.1	type IV secretory system conjugative DNA transfer family protein	-
D4I01_RS07695	1563901..1564458	-	558	WP_139543532.1	hypothetical protein	-
D4I01_RS07700	1564459..1564749	-	291	WP_000159818.1	hypothetical protein	-
D4I01_RS07705	1564746..1565201	-	456	WP_139543533.1	mobilization protein	-
D4I01_RS07710	1565198..1566139	-	942	WP_139543534.1	Flp pilus assembly complex ATPase component TadA	-
D4I01_RS07715	1566139..1566438	-	300	WP_000660141.1	hypothetical protein	-
D4I01_RS07720	1566435..1566698	-	264	WP_139543535.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (1-92)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10874.86 Da
• Isoelectric Point: 10.0264

>T112831 WP_033756152.1 NZ_CP032909:1561617-1561898 [Helicobacter pylori]
MLKVRTKKDFLKDFNKHILSGRITESDVASIVDCLKKQKPLQQKYCDHALSGNLKGLRECHVKPNLLLIYEIKKQENELV
LLRLDTHSELFKK

Nucleotide

• Length: 282 bp

>T112831 NZ_CP032909:1561617-1561898 [Helicobacter pylori]
ATGCTTAAAGTCAGAACTAAGAAAGATTTTCTTAAAGACTTTAATAAGCATATCTTATCTGGGCGTATTACAGAAAGCGA
TGTTGCAAGCATTGTTGATTGCCTAAAAAAACAAAAACCACTCCAACAAAAATATTGCGACCATGCCTTGAGTGGCAATC
TTAAAGGGTTGAGAGAGTGTCATGTCAAGCCAAACTTGTTATTGATTTATGAAATCAAAAAACAAGAAAACGAACTTGTT
TTATTGCGTCTAGACACTCATAGCGAGCTATTTAAAAAGTGA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 12149.66 Da
• Isoelectric Point: 6.2317

>AT112831 WP_139543530.1 NZ_CP032909:1561310-1561624 [Helicobacter pylori]
MSNIITDYSQYNEKQLHNFLNAIKKQLLKAEGDKNKAIKKIQECELQEQMIRQVLAQKHSQEKEPTPSLLNTIASKDDPE
YDVSFGDFNDFLQIAKQERERHNA

Nucleotide

• Length: 315 bp

>AT112831 NZ_CP032909:1561310-1561624 [Helicobacter pylori]
ATGTCAAATATTATTACAGATTATTCGCAATACAATGAAAAACAACTGCATAATTTCTTAAACGCCATTAAAAAACAATT
GCTTAAGGCAGAAGGGGATAAAAATAAAGCGATAAAAAAAATCCAAGAGTGTGAATTGCAAGAACAAATGATCAGACAAG
TTTTAGCCCAAAAACATTCTCAAGAAAAAGAACCCACACCAAGTTTGTTAAATACGATCGCCTCAAAAGATGACCCAGAA
TACGATGTTTCGTTTGGAGACTTCAATGATTTTTTGCAAATAGCAAAACAAGAAAGAGAAAGGCATAATGCTTAA

Structures

Toxin

• AlphaFold DB: A0A496ESF5