Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2121348..2121997 Replicon chromosome
Accession NZ_CP032897
Organism Enterobacter kobei strain WCHEK045523

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag D9T11_RS11680 Protein ID WP_121527586.1
Coordinates 2121635..2121997 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag D9T11_RS11675 Protein ID WP_045134924.1
Coordinates 2121348..2121647 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D9T11_RS11665 2117773..2119746 + 1974 WP_121527584.1 PhoX family phosphatase -
D9T11_RS11670 2119849..2121237 + 1389 WP_121527585.1 phenylalanine transporter -
D9T11_RS11675 2121348..2121647 - 300 WP_045134924.1 helix-turn-helix transcriptional regulator Antitoxin
D9T11_RS11680 2121635..2121997 - 363 WP_121527586.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
D9T11_RS11685 2122203..2123438 + 1236 WP_121527587.1 MFS transporter -
D9T11_RS11690 2123454..2124479 + 1026 WP_121527588.1 sugar phosphate isomerase/epimerase -
D9T11_RS11695 2124472..2125614 + 1143 WP_121527589.1 Gfo/Idh/MocA family oxidoreductase -
D9T11_RS11700 2125690..2126661 + 972 WP_045281665.1 LacI family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-87)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13983.93 Da        Isoelectric Point: 6.2260

>T112796 WP_121527586.1 NZ_CP032897:c2121997-2121635 [Enterobacter kobei]
MWNVETTDRFDQWYFEQTTALKEDVLTMMHILAEFGPTLGRPYVDTVKASAYANMKELRIQHAGNPIRAFFAFDPDRKAI
VLCAGDKTGCNQKRFYNEMITLADVEYSRHLADKEAIWQR

Download         Length: 363 bp

>T112796 NZ_CP032897:c2121997-2121635 [Enterobacter kobei]
ATGTGGAATGTCGAGACAACGGACAGATTTGATCAATGGTACTTCGAACAAACAACAGCATTAAAAGAAGATGTGCTAAC
GATGATGCATATTCTTGCTGAGTTTGGCCCAACGCTTGGGCGGCCATACGTAGATACCGTGAAGGCTTCAGCCTATGCGA
ACATGAAGGAATTACGGATTCAACATGCGGGAAATCCCATCAGAGCTTTTTTTGCTTTTGATCCTGACCGTAAGGCAATT
GTGCTCTGTGCTGGAGACAAAACCGGTTGCAATCAAAAACGGTTTTATAACGAAATGATTACGCTGGCTGACGTTGAGTA
CAGCAGACATCTGGCGGATAAGGAGGCCATATGGCAACGCTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10890.64 Da        Isoelectric Point: 9.8627

>AT112796 WP_045134924.1 NZ_CP032897:c2121647-2121348 [Enterobacter kobei]
MATLKELMAQQSTESQERIAAKVDVIRRIVALNQLREELNISQTELAAAMGVKQPTVAKIEQPGNDPRLSTLKRYVSALG
GEMSIDVTLPNGKRIAFQI

Download         Length: 300 bp

>AT112796 NZ_CP032897:c2121647-2121348 [Enterobacter kobei]
ATGGCAACGCTAAAAGAACTCATGGCACAACAGAGCACGGAAAGTCAGGAGCGTATTGCGGCTAAAGTTGATGTAATACG
CAGAATTGTTGCCCTGAACCAACTGCGGGAAGAGCTCAATATTTCGCAGACAGAACTGGCCGCGGCAATGGGGGTAAAAC
AACCAACTGTGGCAAAAATCGAACAGCCGGGAAACGATCCCCGGCTTTCAACACTCAAACGCTATGTCAGTGCGCTCGGC
GGTGAAATGAGCATTGATGTGACGTTACCGAATGGGAAACGAATAGCGTTTCAGATTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References