Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | I | Classification (family/domain) | hok-sok/- |
Location | 46925..47179 | Replicon | plasmid pCTXM15_000837 |
Accession | NZ_CP032877 | ||
Organism | Escherichia coli strain WCHEC000837 |
Toxin (Protein)
Gene name | srnB | Uniprot ID | - |
Locus tag | D9N32_RS00945 | Protein ID | WP_015387399.1 |
Coordinates | 46973..47179 (+) | Length | 69 a.a. |
Antitoxin (RNA)
Gene name | sok | ||
Locus tag | - | ||
Coordinates | 46925..46986 (-) |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
D9N32_RS00900 | 42577..42789 | + | 213 | WP_005012601.1 | hypothetical protein | - |
D9N32_RS27740 | 43090..43179 | - | 90 | Protein_48 | IS1 family transposase | - |
D9N32_RS00915 | 43234..43911 | + | 678 | WP_001339397.1 | IS66 family insertion sequence hypothetical protein | - |
D9N32_RS00920 | 43911..44258 | + | 348 | WP_000624622.1 | IS66 family insertion sequence element accessory protein TnpB | - |
D9N32_RS00925 | 44278..45849 | + | 1572 | WP_023149734.1 | IS66 family transposase | - |
D9N32_RS00930 | 45887..46503 | - | 617 | Protein_52 | IS1 family transposase | - |
D9N32_RS00935 | 46604..46786 | + | 183 | WP_000968309.1 | hypothetical protein | - |
- | 46925..46986 | - | 62 | NuclAT_2 | - | Antitoxin |
- | 46925..46986 | - | 62 | NuclAT_2 | - | Antitoxin |
- | 46925..46986 | - | 62 | NuclAT_2 | - | Antitoxin |
- | 46925..46986 | - | 62 | NuclAT_2 | - | Antitoxin |
D9N32_RS00945 | 46973..47179 | + | 207 | WP_015387399.1 | type I toxin-antitoxin system Hok family toxin | Toxin |
D9N32_RS00950 | 47463..47720 | + | 258 | WP_000083833.1 | replication regulatory protein RepA | - |
D9N32_RS00960 | 47956..48030 | + | 75 | WP_032336874.1 | RepA leader peptide Tap | - |
D9N32_RS00965 | 48023..48469 | + | 447 | Protein_57 | incFII family plasmid replication initiator RepA | - |
D9N32_RS00970 | 48415..48897 | - | 483 | Protein_58 | VENN motif pre-toxin domain-containing protein | - |
D9N32_RS00975 | 49790..51010 | + | 1221 | WP_000410951.1 | arginine deiminase | - |
D9N32_RS00980 | 51021..51932 | + | 912 | WP_000440183.1 | carbamate kinase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Conjugative plasmid | aac(6')-Ib-cr / blaOXA-1 / aac(3)-IIa / blaCTX-M-15 / aadA5 / qacE / sul1 / mph(A) / tet(B) | - | 1..150853 | 150853 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 69 a.a. Molecular weight: 7720.23 Da Isoelectric Point: 9.3127
>T112716 WP_015387399.1 NZ_CP032877:46973-47179 [Escherichia coli]
MKYLNTTDCSLFLAGRSKFMTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK
MKYLNTTDCSLFLAGRSKFMTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK
Download Length: 207 bp
>T112716 NZ_CP032877:46973-47179 [Escherichia coli]
ATGAAGTACCTTAACACTACTGATTGTAGCCTCTTCCTTGCAGGGAGGTCAAAGTTTATGACGAAATATGCCCTTATCGG
GTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTTATGTGAACTGAATATTCACAGGG
GAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA
ATGAAGTACCTTAACACTACTGATTGTAGCCTCTTCCTTGCAGGGAGGTCAAAGTTTATGACGAAATATGCCCTTATCGG
GTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTTATGTGAACTGAATATTCACAGGG
GAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA
Antitoxin
Download Length: 62 bp
>AT112716 NZ_CP032877:c46986-46925 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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