Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 955824..956329 Replicon chromosome
Accession NZ_CP032825
Organism Arcobacter cryaerophilus D2610

Toxin (Protein)


Gene name yoeB Uniprot ID A0A494T483
Locus tag ACRYD_RS04685 Protein ID WP_066157207.1
Coordinates 955824..956090 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A494TC26
Locus tag ACRYD_RS04690 Protein ID WP_066348712.1
Coordinates 956084..956329 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ACRYD_RS04660 950919..951512 - 594 WP_120986568.1 NAD(P)/FAD-dependent oxidoreductase -
ACRYD_RS04665 951566..952270 - 705 WP_120986570.1 alpha/beta fold hydrolase -
ACRYD_RS04670 952431..952625 + 195 WP_066348707.1 DUF2892 domain-containing protein -
ACRYD_RS04675 952650..953948 - 1299 WP_120986572.1 succinylglutamate desuccinylase/aspartoacylase family protein -
ACRYD_RS04680 954111..955814 + 1704 WP_120988447.1 YdiU family protein -
ACRYD_RS04685 955824..956090 - 267 WP_066157207.1 Txe/YoeB family addiction module toxin Toxin
ACRYD_RS04690 956084..956329 - 246 WP_066348712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ACRYD_RS04695 956541..956951 - 411 WP_066348714.1 hypothetical protein -
ACRYD_RS04700 956976..957302 - 327 WP_120986574.1 hypothetical protein -
ACRYD_RS04705 957867..958097 - 231 WP_066348719.1 hypothetical protein -
ACRYD_RS04710 958236..959771 - 1536 WP_066157210.1 glutamine-hydrolyzing GMP synthase -
ACRYD_RS04715 959825..961276 - 1452 WP_120986576.1 FAD-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(24-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10229.96 Da        Isoelectric Point: 9.9946

>T112598 WP_066157207.1 NZ_CP032825:c956090-955824 [Arcobacter cryaerophilus D2610]
MVNYKLVYTKQAGKDAKKLSNSGLKSKALELLEIISLNPYQNPPPYEKLIGDLNSAISRRINIQHRLVYEVLEDIKTIKV
IRMWSHYE

Download         Length: 267 bp

>T112598 NZ_CP032825:c956090-955824 [Arcobacter cryaerophilus D2610]
ATGGTAAACTATAAACTTGTTTATACTAAACAAGCTGGAAAAGATGCCAAGAAATTATCTAATTCAGGCTTAAAATCAAA
GGCTTTGGAATTATTAGAGATAATTTCTTTAAATCCATATCAAAATCCCCCGCCTTATGAAAAACTAATTGGTGATTTAA
ATAGTGCAATATCAAGAAGAATAAATATTCAACACAGATTAGTTTATGAAGTTTTAGAAGATATTAAAACTATAAAAGTG
ATACGAATGTGGTCACATTATGAGTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9285.55 Da        Isoelectric Point: 4.0606

>AT112598 WP_066348712.1 NZ_CP032825:c956329-956084 [Arcobacter cryaerophilus D2610]
MTKVMTVSQVRADIYNIIDETALTHEPILITGKRTNAVMLSQEDWNAIQETLYLTSIPNMRESIIKGLNTSIEDCDEELE
W

Download         Length: 246 bp

>AT112598 NZ_CP032825:c956329-956084 [Arcobacter cryaerophilus D2610]
ATGACGAAAGTTATGACAGTTAGTCAAGTTCGAGCAGATATTTATAATATTATTGATGAAACAGCATTAACACATGAACC
AATACTTATAACTGGTAAAAGAACAAATGCTGTTATGTTATCTCAAGAAGATTGGAATGCCATCCAAGAGACTTTATATC
TAACATCAATTCCAAATATGAGAGAATCTATAATTAAGGGATTAAATACATCTATTGAAGATTGTGATGAAGAGTTAGAA
TGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A494T483

Antitoxin

Source ID Structure
AlphaFold DB A0A494TC26

References