Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | I | Classification (family/domain) | symER/SymE(toxin) |
Location | 4738842..4739254 | Replicon | chromosome |
Accession | NZ_CP032811 | ||
Organism | Escherichia coli strain ERL03-1416 |
Toxin (Protein)
Gene name | symE | Uniprot ID | Q8FA88 |
Locus tag | D8Z67_RS24155 | Protein ID | WP_000132630.1 |
Coordinates | 4738913..4739254 (+) | Length | 114 a.a. |
Antitoxin (RNA)
Gene name | symR | ||
Locus tag | - | ||
Coordinates | 4738842..4738918 (-) |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
D8Z67_RS24145 | 4735469..4736938 | + | 1470 | WP_001302468.1 | type I restriction-modification system subunit M | - |
D8Z67_RS24150 | 4736938..4738692 | + | 1755 | WP_000110082.1 | restriction endonuclease subunit S | - |
- | 4738842..4738918 | - | 77 | NuclAT_15 | - | Antitoxin |
- | 4738842..4738918 | - | 77 | NuclAT_15 | - | Antitoxin |
- | 4738842..4738918 | - | 77 | NuclAT_15 | - | Antitoxin |
- | 4738842..4738918 | - | 77 | NuclAT_15 | - | Antitoxin |
- | 4738842..4738918 | - | 77 | NuclAT_16 | - | Antitoxin |
- | 4738842..4738918 | - | 77 | NuclAT_16 | - | Antitoxin |
- | 4738842..4738918 | - | 77 | NuclAT_16 | - | Antitoxin |
- | 4738842..4738918 | - | 77 | NuclAT_16 | - | Antitoxin |
D8Z67_RS24155 | 4738913..4739254 | + | 342 | WP_000132630.1 | endoribonuclease SymE | Toxin |
D8Z67_RS24160 | 4739301..4740464 | - | 1164 | WP_001304006.1 | DUF1524 domain-containing protein | - |
D8Z67_RS24165 | 4740512..4741393 | - | 882 | WP_001304007.1 | DUF262 domain-containing protein | - |
D8Z67_RS24170 | 4741490..4741654 | - | 165 | WP_000394274.1 | DUF1127 domain-containing protein | - |
D8Z67_RS24175 | 4741831..4743243 | + | 1413 | WP_000199295.1 | PLP-dependent aminotransferase family protein | - |
D8Z67_RS28520 | 4743486..4743686 | - | 201 | WP_001310455.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Genomic island | - | espX6 | 4731041..4752262 | 21221 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 114 a.a. Molecular weight: 12294.13 Da Isoelectric Point: 8.4982
>T112574 WP_000132630.1 NZ_CP032811:4738913-4739254 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA
Download Length: 342 bp
>T112574 NZ_CP032811:4738913-4739254 [Escherichia coli]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA
Antitoxin
Download Length: 77 bp
>AT112574 NZ_CP032811:c4738918-4738842 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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