Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3272310..3273105 Replicon chromosome
Accession NZ_CP032811
Organism Escherichia coli strain ERL03-1416

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag D8Z67_RS16990 Protein ID WP_000854914.1
Coordinates 3272310..3272684 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0B0VS41
Locus tag D8Z67_RS16995 Protein ID WP_001280954.1
Coordinates 3272731..3273105 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D8Z67_RS16950 3267314..3267805 - 492 WP_001301587.1 DUF1097 domain-containing protein -
D8Z67_RS16955 3267907..3268461 - 555 WP_001001917.1 molecular chaperone YcdY -
D8Z67_RS16960 3268485..3269222 - 738 WP_000283664.1 zinc-binding phosphatase -
D8Z67_RS16965 3269277..3270215 - 939 WP_000351284.1 glyoxylate/hydroxypyruvate reductase GhrA -
D8Z67_RS16975 3270686..3271528 - 843 WP_001280481.1 DUF4942 domain-containing protein -
D8Z67_RS16980 3271613..3271810 - 198 WP_000839282.1 DUF957 domain-containing protein -
D8Z67_RS16985 3271822..3272313 - 492 WP_000976853.1 hypothetical protein -
D8Z67_RS16990 3272310..3272684 - 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
D8Z67_RS16995 3272731..3273105 - 375 WP_001280954.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
D8Z67_RS17000 3273268..3273489 - 222 WP_001220314.1 DUF987 domain-containing protein -
D8Z67_RS17005 3273552..3274028 - 477 WP_001186738.1 RadC family protein -
D8Z67_RS17010 3274044..3274529 - 486 WP_000214398.1 antirestriction protein -
D8Z67_RS17015 3274620..3275438 - 819 WP_001234682.1 DUF945 domain-containing protein -
D8Z67_RS17025 3275778..3276848 - 1071 WP_000102669.1 patatin-like phospholipase family protein -
D8Z67_RS17030 3276845..3277750 - 906 WP_000203541.1 chemotaxis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - csgB / csgD / csgE / csgF / csgG 3263696..3274529 10833


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T112567 WP_000854914.1 NZ_CP032811:c3272684-3272310 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T112567 NZ_CP032811:c3272684-3272310 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13718.51 Da        Isoelectric Point: 6.6249

>AT112567 WP_001280954.1 NZ_CP032811:c3273105-3272731 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT112567 NZ_CP032811:c3273105-3272731 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGAATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0VS41

References