Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symER/SymE(toxin)
Location 4710767..4711179 Replicon chromosome
Accession NZ_CP032805
Organism Escherichia coli strain ERL05-0623

Toxin (Protein)


Gene name symE Uniprot ID Q8FA88
Locus tag D8Z69_RS24075 Protein ID WP_000132630.1
Coordinates 4710838..4711179 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name symR
Locus tag -
Coordinates 4710767..4710843 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D8Z69_RS24065 4707394..4708863 + 1470 WP_001302468.1 type I restriction-modification system subunit M -
D8Z69_RS24070 4708863..4710617 + 1755 WP_000110082.1 restriction endonuclease subunit S -
- 4710767..4710843 - 77 NuclAT_15 - Antitoxin
- 4710767..4710843 - 77 NuclAT_15 - Antitoxin
- 4710767..4710843 - 77 NuclAT_15 - Antitoxin
- 4710767..4710843 - 77 NuclAT_15 - Antitoxin
- 4710767..4710843 - 77 NuclAT_16 - Antitoxin
- 4710767..4710843 - 77 NuclAT_16 - Antitoxin
- 4710767..4710843 - 77 NuclAT_16 - Antitoxin
- 4710767..4710843 - 77 NuclAT_16 - Antitoxin
D8Z69_RS24075 4710838..4711179 + 342 WP_000132630.1 endoribonuclease SymE Toxin
D8Z69_RS24080 4711226..4712389 - 1164 WP_001304006.1 DUF1524 domain-containing protein -
D8Z69_RS27900 4712437..4713317 - 881 Protein_4592 DUF262 domain-containing protein -
D8Z69_RS24095 4713414..4713578 - 165 WP_000394274.1 DUF1127 domain-containing protein -
D8Z69_RS24100 4713755..4715167 + 1413 WP_000199295.1 PLP-dependent aminotransferase family protein -
D8Z69_RS27905 4715410..4715610 - 201 WP_001310455.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - espX6 4702966..4724204 21238


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12294.13 Da        Isoelectric Point: 8.4982

>T112496 WP_000132630.1 NZ_CP032805:4710838-4711179 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

>T112496 NZ_CP032805:4710838-4711179 [Escherichia coli]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA

Antitoxin


Download         Length: 77 bp

>AT112496 NZ_CP032805:c4710843-4710767 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y5T0

Antitoxin

Download structure file

References