Detailed information of TA system TA112451

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2666779..2667004
• Replicon: chromosome
• Accession: NZ_CP032803
• Organism: Escherichia coli strain ERL05-1306

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: -
• Locus tag: D8Z70_RS13920
• Protein ID: WP_000935259.1
• Coordinates: 2666792..2667004 (+)
• Length: 71 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	2666779..2666837 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D8Z70_RS13870	2661844..2662086	+	243	WP_000747948.1	hypothetical protein	-
D8Z70_RS13875	2662070..2662495	+	426	WP_151547382.1	Rha family transcriptional regulator	-
D8Z70_RS13880	2662564..2663607	+	1044	WP_001262402.1	hypothetical protein	-
D8Z70_RS13885	2663600..2664061	+	462	WP_000139447.1	replication protein	-
D8Z70_RS13890	2664095..2664811	+	717	WP_000450627.1	DUF1627 domain-containing protein	-
D8Z70_RS13895	2664844..2665125	+	282	WP_000603384.1	DNA-binding protein	-
D8Z70_RS13900	2665122..2665349	+	228	WP_000699809.1	hypothetical protein	-
D8Z70_RS13905	2665342..2665653	+	312	WP_001289673.1	hypothetical protein	-
D8Z70_RS13910	2665781..2665999	+	219	WP_000683609.1	DUF4014 family protein	-
D8Z70_RS13915	2666001..2666558	+	558	WP_000104474.1	DUF551 domain-containing protein	-
-	2666779..2666837	-	59	-	-	Antitoxin
D8Z70_RS13920	2666792..2667004	+	213	WP_000935259.1	type I toxin-antitoxin system Hok family toxin	Toxin
D8Z70_RS13925	2667124..2667468	+	345	WP_000756596.1	YgiW/YdeI family stress tolerance OB fold protein	-
D8Z70_RS13930	2667590..2667862	+	273	WP_151547383.1	hypothetical protein	-
D8Z70_RS13935	2667864..2668913	+	1050	WP_001265229.1	DUF968 domain-containing protein	-
D8Z70_RS13940	2668926..2669231	+	306	WP_001217444.1	RusA family crossover junction endodeoxyribonuclease	-
D8Z70_RS13945	2669294..2669848	+	555	WP_000640035.1	DUF1133 family protein	-
D8Z70_RS13950	2670073..2670270	+	198	WP_000917763.1	hypothetical protein	-
D8Z70_RS13955	2670406..2671119	+	714	WP_000301797.1	helix-turn-helix domain-containing protein	-
D8Z70_RS13970	2671570..2672001	+	432	WP_001302123.1	tellurite resistance protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	nleG7'	2599890..2736790	136900

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (25-66)

Sequences

Toxin

Protein

• Length: 71 a.a.
• Molecular weight: 7887.47 Da
• Isoelectric Point: 9.2654

>T112451 WP_000935259.1 NZ_CP032803:2666792-2667004 [Escherichia coli]
MLNTCRLASYVPKGKEKQAMKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFVDYESEK

Nucleotide

• Length: 213 bp

>T112451 NZ_CP032803:2666792-2667004 [Escherichia coli]
ATGCTGAACACATGTAGGTTAGCCTCTTACGTGCCGAAAGGCAAGGAGAAGCAGGCTATGAAGCAGCAAAAGGCGATGTT
AATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAAAGACCTCTGCGAGGTGCGAATCC
GAACCGGTCAGACGGAGGTCGCTGTCTTCGTAGACTACGAATCTGAGAAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT112451 NZ_CP032803:c2666837-2666779 [Escherichia coli]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Structures

Antitoxin