112420

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3361738..3362533 Replicon chromosome
Accession NZ_CP032801
Organism Escherichia coli strain ERL06-2442

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag D8Z71_RS17690 Protein ID WP_000854914.1
Coordinates 3361738..3362112 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0B0VS41
Locus tag D8Z71_RS17695 Protein ID WP_001280954.1
Coordinates 3362159..3362533 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D8Z71_RS17650 3356742..3357233 - 492 WP_001301587.1 DUF1097 domain-containing protein -
D8Z71_RS17655 3357335..3357889 - 555 WP_001001917.1 molecular chaperone YcdY -
D8Z71_RS17660 3357913..3358650 - 738 WP_000283664.1 zinc-binding phosphatase -
D8Z71_RS17665 3358705..3359643 - 939 WP_000351284.1 glyoxylate/hydroxypyruvate reductase GhrA -
D8Z71_RS17675 3360114..3360956 - 843 WP_001280481.1 DUF4942 domain-containing protein -
D8Z71_RS17680 3361041..3361238 - 198 WP_000839282.1 DUF957 domain-containing protein -
D8Z71_RS17685 3361250..3361741 - 492 WP_000976853.1 hypothetical protein -
D8Z71_RS17690 3361738..3362112 - 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
D8Z71_RS17695 3362159..3362533 - 375 WP_001280954.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
D8Z71_RS17700 3362696..3362917 - 222 WP_001220314.1 DUF987 domain-containing protein -
D8Z71_RS17705 3362980..3363456 - 477 WP_001186738.1 RadC family protein -
D8Z71_RS17710 3363472..3363957 - 486 WP_000214398.1 antirestriction protein -
D8Z71_RS17715 3364048..3364866 - 819 WP_001234682.1 DUF945 domain-containing protein -
D8Z71_RS17725 3365206..3366276 - 1071 WP_000102669.1 patatin-like phospholipase family protein -
D8Z71_RS17730 3366273..3367178 - 906 WP_000203541.1 chemotaxis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - csgB / csgD / csgE / csgF / csgG 3353124..3363957 10833


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T112420 WP_000854914.1 NZ_CP032801:c3362112-3361738 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T112420 NZ_CP032801:c3362112-3361738 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13718.51 Da        Isoelectric Point: 6.6249

>AT112420 WP_001280954.1 NZ_CP032801:c3362533-3362159 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT112420 NZ_CP032801:c3362533-3362159 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGAATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0VS41

References