Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) ralRA/-
Location 2287782..2288153 Replicon chromosome
Accession NZ_CP032801
Organism Escherichia coli strain ERL06-2442

Toxin (Protein)


Gene name ralR Uniprot ID A0A891STD1
Locus tag D8Z71_RS11730 Protein ID WP_042853000.1
Coordinates 2287959..2288153 (-) Length 65 a.a.

Antitoxin (RNA)


Gene name ralA
Locus tag -
Coordinates 2287782..2287960 (+)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D8Z71_RS11690 2283224..2283880 - 657 WP_000011656.1 carbon-nitrogen hydrolase family protein -
D8Z71_RS11695 2283982..2284212 - 231 WP_000916763.1 DNA polymerase III subunit theta -
D8Z71_RS11700 2284351..2284725 + 375 WP_000168751.1 CopC domain-containing protein YobA -
D8Z71_RS11705 2284729..2285601 + 873 WP_000879314.1 copper homeostasis membrane protein CopD -
D8Z71_RS11710 2285614..2285955 + 342 WP_000976483.1 YebY family protein -
D8Z71_RS11715 2286348..2287424 - 1077 WP_045893699.1 phage integrase Arm DNA-binding domain-containing protein -
D8Z71_RS11720 2287390..2287671 - 282 WP_001311878.1 excisionase -
D8Z71_RS11725 2287778..2287966 - 189 WP_001356607.1 DUF1187 family protein -
- 2287782..2287960 + 179 NuclAT_0 - Antitoxin
- 2287782..2287960 + 179 NuclAT_0 - Antitoxin
- 2287782..2287960 + 179 NuclAT_0 - Antitoxin
- 2287782..2287960 + 179 NuclAT_0 - Antitoxin
D8Z71_RS11730 2287959..2288153 - 195 WP_042853000.1 type I toxin-antitoxin system endodeoxyribonuclease toxin RalR Toxin
D8Z71_RS11735 2288210..2289019 - 810 WP_000166313.1 recombination protein RecT -
D8Z71_RS11740 2289012..2291681 - 2670 WP_000102194.1 exodeoxyribonuclease VIII -
D8Z71_RS11745 2291762..2291938 - 177 WP_000245534.1 hypothetical protein -
D8Z71_RS11750 2291932..2292153 - 222 WP_000560228.1 killing protein KilR -
D8Z71_RS11755 2292200..2293051 - 852 WP_062882198.1 Rha family phage regulatory protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2265903..2347464 81561


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(6-54)


Sequences


Toxin        


Download         Length: 65 a.a.        Molecular weight: 7019.87 Da        Isoelectric Point: 8.6419

>T112414 WP_042853000.1 NZ_CP032801:c2288153-2287959 [Escherichia coli]
MRYDDVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Download         Length: 195 bp

>T112414 NZ_CP032801:c2288153-2287959 [Escherichia coli]
ATGAGATATGACGATGTTAAACCATGTCCGTTTTGTGGTTGTCCATCTGTTACAGTGAAAGCAATTTCAGGATATTACCG
GGCAAAATGCAACGGATGCGAATCCCGAACTGGCTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CTACTGGAAATAATAATGGAGGTGTTCATGTATAA

Antitoxin


Download         Length: 179 bp

>AT112414 NZ_CP032801:2287782-2287960 [Escherichia coli]
GAGGACAGAAGTTTCTCGCAATTAAAATTTATCAGCTTTACTTTCTGCTCTCTGGACACGCCTGCTTCTTTTTTCCCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAATTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCTTTTT
CAATAGTGGCAGTTATTTT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Download structure file

References