Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symER/SymE(toxin)
Location 4825278..4825690 Replicon chromosome
Accession NZ_CP032797
Organism Escherichia coli strain ERL06-2497

Toxin (Protein)


Gene name symE Uniprot ID Q8FA88
Locus tag D8Z72_RS24950 Protein ID WP_000132630.1
Coordinates 4825349..4825690 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name symR
Locus tag -
Coordinates 4825278..4825354 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D8Z72_RS24940 4821905..4823374 + 1470 WP_001302468.1 type I restriction-modification system subunit M -
D8Z72_RS24945 4823374..4825128 + 1755 WP_000110082.1 restriction endonuclease subunit S -
- 4825278..4825354 - 77 NuclAT_15 - Antitoxin
- 4825278..4825354 - 77 NuclAT_15 - Antitoxin
- 4825278..4825354 - 77 NuclAT_15 - Antitoxin
- 4825278..4825354 - 77 NuclAT_15 - Antitoxin
- 4825278..4825354 - 77 NuclAT_16 - Antitoxin
- 4825278..4825354 - 77 NuclAT_16 - Antitoxin
- 4825278..4825354 - 77 NuclAT_16 - Antitoxin
- 4825278..4825354 - 77 NuclAT_16 - Antitoxin
D8Z72_RS24950 4825349..4825690 + 342 WP_000132630.1 endoribonuclease SymE Toxin
D8Z72_RS24955 4825737..4826900 - 1164 WP_001304006.1 DUF1524 domain-containing protein -
D8Z72_RS29240 4826948..4827828 - 881 Protein_4755 DUF262 domain-containing protein -
D8Z72_RS24970 4827925..4828089 - 165 WP_000394274.1 DUF1127 domain-containing protein -
D8Z72_RS24975 4828266..4829678 + 1413 WP_000199295.1 PLP-dependent aminotransferase family protein -
D8Z72_RS29245 4829921..4830121 - 201 WP_001310455.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - espX6 4817477..4838715 21238


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12294.13 Da        Isoelectric Point: 8.4982

>T112386 WP_000132630.1 NZ_CP032797:4825349-4825690 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

>T112386 NZ_CP032797:4825349-4825690 [Escherichia coli]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA

Antitoxin


Download         Length: 77 bp

>AT112386 NZ_CP032797:c4825354-4825278 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y5T0

Antitoxin

Download structure file

References