Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1981554..1982349 Replicon chromosome
Accession NZ_CP032797
Organism Escherichia coli strain ERL06-2497

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag D8Z72_RS09930 Protein ID WP_000854914.1
Coordinates 1981975..1982349 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0B0VS41
Locus tag D8Z72_RS09925 Protein ID WP_001280954.1
Coordinates 1981554..1981928 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D8Z72_RS09890 1976909..1977814 + 906 WP_000203541.1 chemotaxis protein -
D8Z72_RS09895 1977811..1978881 + 1071 WP_000102669.1 patatin-like phospholipase family protein -
D8Z72_RS09905 1979221..1980039 + 819 WP_001234682.1 DUF945 domain-containing protein -
D8Z72_RS09910 1980130..1980615 + 486 WP_000214398.1 antirestriction protein -
D8Z72_RS09915 1980631..1981107 + 477 WP_001186738.1 RadC family protein -
D8Z72_RS09920 1981170..1981391 + 222 WP_001220314.1 DUF987 domain-containing protein -
D8Z72_RS09925 1981554..1981928 + 375 WP_001280954.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
D8Z72_RS09930 1981975..1982349 + 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
D8Z72_RS09935 1982346..1982837 + 492 WP_000976853.1 hypothetical protein -
D8Z72_RS09940 1982849..1983046 + 198 WP_000839282.1 DUF957 domain-containing protein -
D8Z72_RS09945 1983131..1983973 + 843 WP_001280481.1 DUF4942 domain-containing protein -
D8Z72_RS09955 1984444..1985382 + 939 WP_000351284.1 glyoxylate/hydroxypyruvate reductase GhrA -
D8Z72_RS09960 1985437..1986174 + 738 WP_000283664.1 zinc-binding phosphatase -
D8Z72_RS09965 1986198..1986752 + 555 WP_001001917.1 molecular chaperone YcdY -
D8Z72_RS09970 1986854..1987345 + 492 WP_001301587.1 DUF1097 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - csgG / csgF / csgE / csgD / csgB / csgA / csgC 1980631..1992913 12282


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T112369 WP_000854914.1 NZ_CP032797:1981975-1982349 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T112369 NZ_CP032797:1981975-1982349 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13718.51 Da        Isoelectric Point: 6.6249

>AT112369 WP_001280954.1 NZ_CP032797:1981554-1981928 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT112369 NZ_CP032797:1981554-1981928 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGAATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0VS41

References