Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2978157..2978952 Replicon chromosome
Accession NZ_CP032791
Organism Escherichia coli strain NZRM4165

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag D8Z75_RS15385 Protein ID WP_000854914.1
Coordinates 2978157..2978531 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0B0VS41
Locus tag D8Z75_RS15390 Protein ID WP_001280954.1
Coordinates 2978578..2978952 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D8Z75_RS15345 2973161..2973652 - 492 WP_001301587.1 DUF1097 domain-containing protein -
D8Z75_RS15350 2973754..2974308 - 555 WP_001001917.1 molecular chaperone YcdY -
D8Z75_RS15355 2974332..2975069 - 738 WP_000283664.1 zinc-binding phosphatase -
D8Z75_RS15360 2975124..2976062 - 939 WP_000351284.1 glyoxylate/hydroxypyruvate reductase GhrA -
D8Z75_RS15370 2976533..2977375 - 843 WP_001280481.1 DUF4942 domain-containing protein -
D8Z75_RS15375 2977460..2977657 - 198 WP_000839282.1 DUF957 domain-containing protein -
D8Z75_RS15380 2977669..2978160 - 492 WP_000976853.1 hypothetical protein -
D8Z75_RS15385 2978157..2978531 - 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
D8Z75_RS15390 2978578..2978952 - 375 WP_001280954.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
D8Z75_RS15395 2979115..2979336 - 222 WP_001220314.1 DUF987 domain-containing protein -
D8Z75_RS15400 2979399..2979875 - 477 WP_001186738.1 RadC family protein -
D8Z75_RS15405 2979891..2980376 - 486 WP_000214398.1 antirestriction protein -
D8Z75_RS15410 2980467..2981285 - 819 WP_001234682.1 DUF945 domain-containing protein -
D8Z75_RS15420 2981625..2982695 - 1071 WP_000102660.1 patatin-like phospholipase family protein -
D8Z75_RS15425 2982692..2983597 - 906 WP_000203545.1 chemotaxis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - csgB / csgD / csgE / csgF / csgG 2969543..2980376 10833


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T112273 WP_000854914.1 NZ_CP032791:c2978531-2978157 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T112273 NZ_CP032791:c2978531-2978157 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13718.51 Da        Isoelectric Point: 6.6249

>AT112273 WP_001280954.1 NZ_CP032791:c2978952-2978578 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT112273 NZ_CP032791:c2978952-2978578 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGAATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0VS41

References