Detailed information of TA system TA112252

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-sokW/Ldr(toxin)
• Location: 278421..278642
• Replicon: chromosome
• Accession: NZ_CP032791
• Organism: Escherichia coli strain NZRM4165

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: D8Z75_RS01375
• Protein ID: WP_001295224.1
• Coordinates: 278535..278642 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	278421..278486 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D8Z75_RS01350	273861..274763	+	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-
D8Z75_RS01355	274774..275757	+	984	WP_151589211.1	dipeptide ABC transporter ATP-binding protein	-
D8Z75_RS01360	275754..276758	+	1005	WP_000107027.1	dipeptide ABC transporter ATP-binding subunit DppF	-
D8Z75_RS01365	276788..278059	-	1272	WP_001301684.1	amino acid permease	-
-	278421..278486	-	66	NuclAT_16	-	Antitoxin
-	278421..278486	-	66	NuclAT_16	-	Antitoxin
-	278421..278486	-	66	NuclAT_16	-	Antitoxin
-	278421..278486	-	66	NuclAT_16	-	Antitoxin
-	278421..278486	-	66	NuclAT_21	-	Antitoxin
-	278421..278486	-	66	NuclAT_21	-	Antitoxin
-	278421..278486	-	66	NuclAT_21	-	Antitoxin
-	278421..278486	-	66	NuclAT_21	-	Antitoxin
D8Z75_RS01375	278535..278642	+	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
D8Z75_RS01380	278729..280408	-	1680	WP_000191596.1	cellulose biosynthesis protein BcsG	-
D8Z75_RS01385	280405..280596	-	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
D8Z75_RS01390	280593..282164	-	1572	WP_001204920.1	cellulose biosynthesis protein BcsE	-
D8Z75_RS01395	282437..282625	+	189	WP_001063316.1	YhjR family protein	-
D8Z75_RS01400	282637..282834	+	198	WP_000279508.1	AAA family ATPase	-
D8Z75_RS01405	282853..283389	+	537	WP_001270903.1	cellulose synthase operon protein YhjQ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T112252 WP_001295224.1 NZ_CP032791:278535-278642 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T112252 NZ_CP032791:278535-278642 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 66 bp

>AT112252 NZ_CP032791:c278486-278421 [Escherichia coli]
GTCTAGGTTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin