Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symER/SymE(toxin)
Location 4783167..4783579 Replicon chromosome
Accession NZ_CP032789
Organism Escherichia coli strain NZRM4169

Toxin (Protein)


Gene name symE Uniprot ID Q8FA88
Locus tag D8Z76_RS24645 Protein ID WP_000132630.1
Coordinates 4783238..4783579 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name symR
Locus tag -
Coordinates 4783167..4783243 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D8Z76_RS24635 4779794..4781263 + 1470 WP_001302468.1 type I restriction-modification system subunit M -
D8Z76_RS24640 4781263..4783017 + 1755 WP_000110082.1 restriction endonuclease subunit S -
- 4783167..4783243 - 77 NuclAT_15 - Antitoxin
- 4783167..4783243 - 77 NuclAT_15 - Antitoxin
- 4783167..4783243 - 77 NuclAT_15 - Antitoxin
- 4783167..4783243 - 77 NuclAT_15 - Antitoxin
- 4783167..4783243 - 77 NuclAT_16 - Antitoxin
- 4783167..4783243 - 77 NuclAT_16 - Antitoxin
- 4783167..4783243 - 77 NuclAT_16 - Antitoxin
- 4783167..4783243 - 77 NuclAT_16 - Antitoxin
D8Z76_RS24645 4783238..4783579 + 342 WP_000132630.1 endoribonuclease SymE Toxin
D8Z76_RS24650 4783626..4784789 - 1164 WP_001304006.1 DUF1524 domain-containing protein -
D8Z76_RS24655 4784837..4785718 - 882 WP_001304007.1 DUF262 domain-containing protein -
D8Z76_RS24660 4785815..4785979 - 165 WP_000394274.1 DUF1127 domain-containing protein -
D8Z76_RS24665 4786156..4787568 + 1413 WP_000199295.1 PLP-dependent aminotransferase family protein -
D8Z76_RS28805 4787811..4788011 - 201 WP_001310455.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - espX6 4775366..4796590 21224


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12294.13 Da        Isoelectric Point: 8.4982

>T112246 WP_000132630.1 NZ_CP032789:4783238-4783579 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

>T112246 NZ_CP032789:4783238-4783579 [Escherichia coli]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA

Antitoxin


Download         Length: 77 bp

>AT112246 NZ_CP032789:c4783243-4783167 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y5T0

Antitoxin

Download structure file

References