Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 442819..443471 Replicon chromosome
Accession NZ_CP032738
Organism Serratia sp. 1D1416

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag D7I37_RS02125 Protein ID WP_095099029.1
Coordinates 442819..443163 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag D7I37_RS02130 Protein ID WP_061796825.1
Coordinates 443169..443471 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D7I37_RS02110 438022..440289 - 2268 WP_129543228.1 molybdopterin guanine dinucleotide-containing S/N-oxide reductase -
D7I37_RS02115 440511..441530 + 1020 WP_061796819.1 HTH-type transcriptional regulator GalR -
D7I37_RS02120 441669..442679 + 1011 WP_129543229.1 LacI family DNA-binding transcriptional regulator -
D7I37_RS02125 442819..443163 + 345 WP_095099029.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
D7I37_RS02130 443169..443471 + 303 WP_061796825.1 helix-turn-helix transcriptional regulator Antitoxin
D7I37_RS02135 443500..444762 - 1263 WP_129543230.1 diaminopimelate decarboxylase -
D7I37_RS02140 444896..445819 + 924 WP_061796828.1 LysR family transcriptional regulator -
D7I37_RS02145 445809..446963 - 1155 WP_061796830.1 MFS transporter -
D7I37_RS02150 447282..448190 - 909 WP_061796832.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(18-89)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13252.31 Da        Isoelectric Point: 10.1599

>T112184 WP_095099029.1 NZ_CP032738:442819-443163 [Serratia sp. 1D1416]
MWQVATVEIFDAWFLSLSGDQQKSILAGIFKLQEFGPQLARPYADTLHFPGSIHRMKELRIQHRGHPFRFFFAFDPQRQA
VLLCGGDKTGDKRFCQRLLPIAAREFSHYLATQR

Download         Length: 345 bp

>T112184 NZ_CP032738:442819-443163 [Serratia sp. 1D1416]
ATGTGGCAGGTCGCGACCGTCGAAATATTCGACGCCTGGTTTTTATCGCTGAGTGGCGACCAGCAAAAAAGCATCCTGGC
GGGGATTTTCAAACTGCAGGAATTCGGCCCCCAGCTGGCAAGGCCATATGCCGACACGCTGCATTTTCCCGGTTCAATAC
ACCGCATGAAAGAGCTGCGCATTCAACACCGCGGCCACCCGTTTCGGTTTTTTTTCGCCTTCGATCCACAACGGCAGGCG
GTGCTGTTGTGCGGTGGCGACAAAACCGGCGACAAGCGTTTCTGCCAGCGCCTGTTGCCCATCGCCGCCAGGGAGTTCTC
ACATTATCTGGCAACCCAGAGGTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11118.04 Da        Isoelectric Point: 10.4666

>AT112184 WP_061796825.1 NZ_CP032738:443169-443471 [Serratia sp. 1D1416]
MAKPLSHLIDKLDPAVVAAARQKADQEIFELRLAMLREELAVSQVELAKRLGISQPSVANLEKRGSEIKLSSLKRYIEAM
GGTLSLDVRLPNGQHRRMTL

Download         Length: 303 bp

>AT112184 NZ_CP032738:443169-443471 [Serratia sp. 1D1416]
ATGGCCAAACCTTTATCCCATCTGATCGATAAGCTCGATCCCGCCGTCGTTGCGGCGGCCAGGCAAAAAGCGGACCAAGA
AATTTTTGAACTGCGGCTGGCGATGCTGCGGGAAGAGTTGGCGGTTTCGCAGGTTGAGCTGGCGAAGCGGCTTGGCATCA
GCCAACCCTCAGTCGCCAACCTGGAAAAACGCGGCAGCGAGATAAAACTGTCTTCGCTTAAACGCTATATAGAAGCCATG
GGCGGTACGCTGTCGCTGGATGTCCGACTGCCCAACGGCCAGCACCGCCGCATGACGCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References