Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 331426..332038 Replicon chromosome
Accession NZ_CP032689
Organism Rhizobium sp. CCGE532

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag CCGE532_RS01620 Protein ID WP_120662629.1
Coordinates 331742..332038 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CCGE532_RS01615 Protein ID WP_120662628.1
Coordinates 331426..331731 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCGE532_RS01585 326712..327104 + 393 WP_120662622.1 cytidine deaminase -
CCGE532_RS01590 327101..327907 + 807 WP_120662623.1 purine-nucleoside phosphorylase -
CCGE532_RS01595 327904..328677 + 774 WP_120662624.1 deoxyribose-phosphate aldolase -
CCGE532_RS01600 328681..329988 + 1308 WP_120662625.1 thymidine phosphorylase -
CCGE532_RS01605 330042..330566 - 525 WP_120662626.1 TIGR02281 family clan AA aspartic protease -
CCGE532_RS01610 330694..331323 - 630 WP_120662627.1 uracil phosphoribosyltransferase -
CCGE532_RS01615 331426..331731 - 306 WP_120662628.1 HigA family addiction module antidote protein Antitoxin
CCGE532_RS01620 331742..332038 - 297 WP_120662629.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CCGE532_RS01625 332103..333074 - 972 WP_120662630.1 adenosine deaminase -
CCGE532_RS01630 333071..334291 - 1221 WP_120662631.1 phosphopentomutase -
CCGE532_RS01635 334444..335016 - 573 WP_120666362.1 pilus assembly protein -
CCGE532_RS01640 335031..335666 - 636 WP_120662632.1 pilus assembly protein -
CCGE532_RS01645 335821..336243 - 423 WP_120662633.1 pilus assembly protein N-terminal domain-containing protein -
CCGE532_RS01655 336648..336830 + 183 WP_120666366.1 Flp family type IVb pilin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-95)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(5-84)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11630.12 Da        Isoelectric Point: 6.2233

>T112149 WP_120662629.1 NZ_CP032689:c332038-331742 [Rhizobium sp. CCGE532]
MIVSFRDDWLRDFFVEDVHSKKVPADLDSRLFRKLQMIDDAVTDQDLRIPPSNHFEKLRGNLEGFCSVRVNKQWRLIFQW
DGGRGEATGIYLDDHSYR

Download         Length: 297 bp

>T112149 NZ_CP032689:c332038-331742 [Rhizobium sp. CCGE532]
ATGATCGTAAGCTTTCGAGATGATTGGCTGCGTGATTTCTTTGTCGAAGATGTACACTCGAAGAAAGTCCCGGCCGATCT
GGATAGCCGGCTGTTTCGCAAGCTCCAGATGATCGATGATGCGGTGACGGACCAAGATCTACGGATTCCCCCCAGCAATC
ATTTCGAAAAATTGCGCGGCAATCTCGAAGGTTTTTGCTCCGTCCGTGTCAACAAGCAATGGCGGCTTATCTTTCAATGG
GATGGTGGCCGTGGCGAAGCGACGGGCATCTATCTGGACGACCATAGCTATCGGTAG

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11513.30 Da        Isoelectric Point: 9.4083

>AT112149 WP_120662628.1 NZ_CP032689:c331731-331426 [Rhizobium sp. CCGE532]
MLMTKRKPASVGEILVEEFMEPMGLTQSALAEAMGVQRKHVNELCNNRRSVTAATALILARVFGNSPEFWLNVQRRNDLW
DVMHSPHERERIERARPLSAA

Download         Length: 306 bp

>AT112149 NZ_CP032689:c331731-331426 [Rhizobium sp. CCGE532]
ATGTTGATGACAAAACGTAAGCCGGCAAGTGTCGGCGAAATATTGGTCGAAGAATTCATGGAGCCCATGGGCCTGACGCA
AAGTGCGTTGGCCGAGGCCATGGGCGTCCAGCGAAAGCATGTGAATGAACTATGCAATAATCGCCGCAGCGTGACGGCTG
CAACGGCACTCATCCTTGCTCGCGTGTTCGGCAATAGCCCGGAGTTCTGGCTGAACGTTCAACGGCGCAATGACCTGTGG
GACGTCATGCACTCTCCGCACGAGCGCGAGCGAATCGAGCGCGCCCGTCCGTTGTCCGCAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References