Detailed information of TA system TA111996

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 1785072..1785775
• Replicon: chromosome
• Accession: NZ_CP032616
• Organism: Pseudomonas sp. DY-1

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: D6Z43_RS08615
• Protein ID: WP_120651544.1
• Coordinates: 1785072..1785368 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: -
• Locus tag: D6Z43_RS08620
• Protein ID: WP_120651545.1
• Coordinates: 1785371..1785775 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D6Z43_RS08600	1781669..1782715	-	1047	Protein_1655	DUF1254 domain-containing protein	-
D6Z43_RS08605	1782714..1783367	-	654	Protein_1656	phage portal protein	-
D6Z43_RS08610	1783590..1784912	+	1323	WP_162945820.1	hypothetical protein	-
D6Z43_RS08615	1785072..1785368	+	297	WP_120651544.1	type II toxin-antitoxin system MqsR family toxin	Toxin
D6Z43_RS08620	1785371..1785775	+	405	WP_120651545.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
D6Z43_RS08630	1786376..1787065	+	690	WP_120651546.1	crotonase/enoyl-CoA hydratase family protein	-
D6Z43_RS27850	1787107..1787520	+	414	WP_162945821.1	hypothetical protein	-
D6Z43_RS08635	1787683..1788540	-	858	WP_120651547.1	alpha/beta fold hydrolase	-
D6Z43_RS08640	1788698..1789669	+	972	WP_120651548.1	magnesium and cobalt transport protein CorA	-
D6Z43_RS08645	1789749..1790468	-	720	WP_120651549.1	amidotransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (5-97)

Antitoxin

• Cro/C1-type helix-turn-helix domain (72-125)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11285.09 Da
• Isoelectric Point: 6.4653

>T111996 WP_120651544.1 NZ_CP032616:1785072-1785368 [Pseudomonas sp. DY-1]
MEKRTPHFKLVLVKQAAAEQRYRFTRVALEGGAELGLDIDGMLAIIQALTARDFYKSMTTYADHTLWQDVYRPTTDVGQL
YLKFTLVEDLLIVSFKEL

Nucleotide

• Length: 297 bp

>T111996 NZ_CP032616:1785072-1785368 [Pseudomonas sp. DY-1]
ATGGAGAAGCGCACACCACACTTCAAGCTGGTATTGGTCAAGCAAGCCGCTGCGGAGCAGCGATACCGCTTCACACGAGT
GGCCCTGGAAGGTGGCGCGGAACTGGGTCTGGACATCGACGGCATGCTCGCCATCATCCAGGCCCTCACCGCTCGCGACT
TCTACAAGAGCATGACCACCTACGCCGACCACACCCTCTGGCAGGACGTTTACCGCCCCACCACCGACGTCGGCCAGCTT
TACCTCAAGTTCACCCTGGTGGAGGACCTTCTCATCGTGTCCTTCAAGGAGCTCTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14721.01 Da
• Isoelectric Point: 8.4887

>AT111996 WP_120651545.1 NZ_CP032616:1785371-1785775 [Pseudomonas sp. DY-1]
MKCPVCGQAYLVHDVRDIPYIYKGESTLIPNVEADWCNACGESLTGPAESKRVMLAMNLARQQVNARAGHLELIKAVRKQ
LKLTQKQAGELFGGGPNAFSRYEKGDVDAPTALVKLFQLLQKHPELGDEVKRAG

Nucleotide

• Length: 405 bp

>AT111996 NZ_CP032616:1785371-1785775 [Pseudomonas sp. DY-1]
ATGAAATGCCCGGTATGCGGCCAGGCCTACCTGGTCCACGACGTTCGCGACATTCCGTACATCTACAAGGGCGAAAGCAC
CCTCATCCCCAACGTAGAAGCGGACTGGTGCAACGCCTGCGGAGAGTCCCTCACAGGTCCGGCGGAATCCAAGCGAGTCA
TGCTGGCAATGAACCTTGCCCGGCAGCAGGTCAACGCACGCGCCGGGCACCTAGAGCTGATCAAGGCCGTACGCAAGCAG
CTCAAGCTCACCCAGAAGCAAGCGGGCGAGCTGTTCGGTGGCGGCCCTAATGCATTCAGTCGCTACGAGAAAGGCGACGT
GGATGCGCCCACAGCGCTGGTGAAGCTGTTCCAGCTGCTCCAGAAGCATCCCGAGCTGGGGGATGAGGTAAAGCGCGCTG
GCTGA