Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 5217..5824 Replicon chromosome
Accession NZ_CP032616
Organism Pseudomonas sp. DY-1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag D6Z43_RS00235 Protein ID WP_120649741.1
Coordinates 5217..5531 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag D6Z43_RS00240 Protein ID WP_120649742.1
Coordinates 5537..5824 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D6Z43_RS00205 500..808 + 309 WP_120649759.1 hypothetical protein -
D6Z43_RS00210 835..1209 + 375 WP_162945788.1 hypothetical protein -
D6Z43_RS00215 1209..1535 + 327 WP_120649754.1 DUF2523 domain-containing protein -
D6Z43_RS00220 1548..2723 + 1176 WP_120649738.1 zonular occludens toxin -
D6Z43_RS00225 2889..4166 + 1278 WP_120649739.1 hypothetical protein -
D6Z43_RS00230 4148..5173 + 1026 WP_120649740.1 tyrosine-type recombinase/integrase -
D6Z43_RS00235 5217..5531 + 315 WP_120649741.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
D6Z43_RS00240 5537..5824 + 288 WP_120649742.1 helix-turn-helix domain-containing protein Antitoxin
D6Z43_RS00245 6149..6901 + 753 WP_120649743.1 hypothetical protein -
D6Z43_RS00250 7056..8243 - 1188 WP_120649744.1 hypothetical protein -
D6Z43_RS00255 8252..9430 - 1179 WP_120649745.1 hypothetical protein -
D6Z43_RS00260 9570..9845 - 276 WP_120649746.1 helix-turn-helix transcriptional regulator -
D6Z43_RS00265 9973..10188 + 216 WP_120649747.1 DNA-binding protein -
D6Z43_RS00270 10185..10475 + 291 WP_120649748.1 hypothetical protein -
D6Z43_RS00275 10535..10702 + 168 WP_120649749.1 DNA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(43-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(35-86)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11895.67 Da        Isoelectric Point: 10.0550

>T111994 WP_120649741.1 NZ_CP032616:5217-5531 [Pseudomonas sp. DY-1]
MIFIETPIFTKRLRELLSDDSYAAFQRQLAERPDMGDVIEGTGGIRKVRVASGGHGKRGGSRVIYYHFTSASQIALLLIY
PKNEKDDLSADERKVLKQIIERWR

Download         Length: 315 bp

>T111994 NZ_CP032616:5217-5531 [Pseudomonas sp. DY-1]
ATGATCTTTATTGAGACTCCGATCTTCACCAAGCGTCTGCGTGAGTTGCTCAGCGACGACAGCTATGCGGCGTTTCAGCG
CCAGTTGGCCGAGCGGCCGGATATGGGCGACGTGATCGAAGGCACCGGAGGTATTCGCAAAGTGCGTGTCGCCTCGGGTG
GACACGGTAAGCGGGGCGGGTCCAGGGTCATCTACTACCACTTCACTTCGGCTTCGCAGATTGCACTGCTGCTGATCTAC
CCGAAGAACGAGAAGGATGATCTGTCGGCCGATGAGCGAAAGGTGCTCAAGCAAATCATTGAGCGGTGGAGGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10862.45 Da        Isoelectric Point: 10.0108

>AT111994 WP_120649742.1 NZ_CP032616:5537-5824 [Pseudomonas sp. DY-1]
MSKFFEDLLESVQQMDEIHRGERKPSREFTVDALQVKEIRKATGLTQAKFAAMIDVQLGTLRNWEQGRREPTGPAKALLR
AIHNDPKHVIQALSH

Download         Length: 288 bp

>AT111994 NZ_CP032616:5537-5824 [Pseudomonas sp. DY-1]
ATGAGCAAATTCTTTGAAGACCTTCTGGAAAGCGTCCAGCAAATGGACGAGATCCACCGTGGCGAGCGTAAGCCTTCACG
GGAGTTCACCGTGGACGCGCTGCAGGTGAAGGAAATCCGCAAGGCCACTGGCCTGACCCAAGCCAAGTTTGCGGCCATGA
TCGATGTGCAGCTCGGCACGTTGCGCAACTGGGAACAAGGTCGGCGTGAACCCACTGGCCCGGCCAAGGCGCTGCTGCGG
GCCATCCACAATGACCCCAAACACGTCATCCAGGCACTGTCTCACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References