Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 41336..41600 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP032524 | ||
| Organism | Shigella sonnei strain AR_0030 | ||
Toxin (Protein)
| Gene name | pndA | Uniprot ID | U9Z417 |
| Locus tag | AM357_RS26315 | Protein ID | WP_001387489.1 |
| Coordinates | 41448..41600 (+) | Length | 51 a.a. |
Antitoxin (RNA)
| Gene name | pndB | ||
| Locus tag | - | ||
| Coordinates | 41336..41398 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AM357_RS26300 (37438) | 37438..38508 | - | 1071 | WP_000151588.1 | IncI1-type conjugal transfer protein TrbB | - |
| AM357_RS26305 (38527) | 38527..39735 | - | 1209 | WP_000121263.1 | IncI1-type conjugal transfer protein TrbA | - |
| AM357_RS26310 (40042) | 40042..40821 | - | 780 | WP_275450201.1 | protein FinQ | - |
| - (41336) | 41336..41398 | - | 63 | NuclAT_0 | - | Antitoxin |
| - (41336) | 41336..41398 | - | 63 | NuclAT_0 | - | Antitoxin |
| - (41336) | 41336..41398 | - | 63 | NuclAT_0 | - | Antitoxin |
| - (41336) | 41336..41398 | - | 63 | NuclAT_0 | - | Antitoxin |
| AM357_RS26315 (41448) | 41448..41600 | + | 153 | WP_001387489.1 | Hok/Gef family protein | Toxin |
| AM357_RS26320 (41672) | 41672..41923 | - | 252 | WP_001291964.1 | hypothetical protein | - |
| AM357_RS27695 (42424) | 42424..42519 | + | 96 | WP_000609148.1 | DinQ-like type I toxin DqlB | - |
| AM357_RS27020 (42584) | 42584..42760 | - | 177 | WP_001054898.1 | hypothetical protein | - |
| AM357_RS27025 (42757) | 42757..42900 | - | 144 | WP_001032823.1 | hypothetical protein | - |
| AM357_RS26330 (42943) | 42943..43152 | - | 210 | WP_001140543.1 | hemolysin expression modulator Hha | - |
| AM357_RS26335 (43250) | 43250..43864 | - | 615 | WP_000578648.1 | plasmid IncI1-type surface exclusion protein ExcA | - |
| AM357_RS26340 (43940) | 43940..46108 | - | 2169 | WP_000698360.1 | IncI1-type conjugal transfer membrane protein TraY | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | blaTEM-1B | - | 1..94537 | 94537 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 51 a.a. Molecular weight: 5761.10 Da Isoelectric Point: 8.7948
>T111951 WP_001387489.1 NZ_CP032524:41448-41600 [Shigella sonnei]
MPQRTFLMMLIVVCVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR
MPQRTFLMMLIVVCVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR
Download Length: 153 bp
>T111951 NZ_CP032524:41448-41600 [Shigella sonnei]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCGTCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCGTCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA
Antitoxin
Download Length: 63 bp
>AT111951 NZ_CP032524:c41398-41336 [Shigella sonnei]
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
