Detailed information of TA system TA111924

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 182409..183132
• Replicon: chromosome
• Accession: NZ_CP032519
• Organism: Cupriavidus oxalaticus strain T2

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: D2917_RS13655
• Protein ID: WP_151071017.1
• Coordinates: 182409..182705 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: A0A375FUY7
• Locus tag: D2917_RS13660
• Protein ID: WP_063241137.1
• Coordinates: 182731..183132 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D2917_RS13640	178062..179027	+	966	WP_151071014.1	M48 family metallopeptidase	-
D2917_RS13645	179112..181193	+	2082	WP_151071015.1	S8 family peptidase	-
D2917_RS13650	181281..182228	-	948	WP_151071016.1	N-acetyl-gamma-glutamyl-phosphate reductase	-
D2917_RS13655	182409..182705	+	297	WP_151071017.1	type II toxin-antitoxin system MqsR family toxin	Toxin
D2917_RS13660	182731..183132	+	402	WP_063241137.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
D2917_RS13665	183142..183918	-	777	WP_151071018.1	exodeoxyribonuclease III	-
D2917_RS13670	183946..184644	+	699	WP_151071019.1	orotate phosphoribosyltransferase	-
D2917_RS13675	184733..186058	+	1326	WP_151071020.1	patatin-like phospholipase family protein	-
D2917_RS13680	186131..186940	-	810	WP_063241140.1	polyphosphate kinase 2 family protein	-
D2917_RS13685	187039..187905	-	867	WP_151071021.1	diaminopimelate epimerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (3-96)

Antitoxin

• Antitoxin MqsA (3-131)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 10987.71 Da
• Isoelectric Point: 9.6781

>T111924 WP_151071017.1 NZ_CP032519:182409-182705 [Cupriavidus oxalaticus]
MGKGTAHYPLWRVRELIAGGLVNLTTSAFEGARNMSLTRADVLDVVAGLQPADFYKSMTTYTDHTVWQDVYRPSTPYGSI
YLKLTVVEKVLIMSFKAR

Nucleotide

• Length: 297 bp

>T111924 NZ_CP032519:182409-182705 [Cupriavidus oxalaticus]
ATGGGGAAGGGGACGGCGCATTACCCGCTGTGGCGGGTGCGGGAGTTGATTGCTGGCGGGTTGGTCAACTTGACTACATC
GGCCTTTGAGGGTGCGAGAAATATGTCACTTACTCGCGCCGACGTGCTCGACGTAGTGGCTGGACTGCAACCGGCTGACT
TCTACAAGAGCATGACGACCTACACCGACCATACCGTTTGGCAGGATGTATATCGGCCGAGTACGCCGTATGGATCAATT
TATCTCAAGCTGACGGTTGTTGAAAAAGTCCTGATCATGTCCTTCAAGGCCCGCTAG

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14822.13 Da
• Isoelectric Point: 7.6324

>AT111924 WP_063241137.1 NZ_CP032519:182731-183132 [Cupriavidus oxalaticus]
MQCPVCGGAKLERRRKDFVYTYRGESTVFEAVLADWCPKCGEGVLDAEEEERIGPLALAFNKQVNASLIDPAYITGVRKK
LRLDQREAAEIFGGGVNAFSRYETGKTKPPLALVKLLKLLDRHPELLEEVRAA

Nucleotide

• Length: 402 bp

>AT111924 NZ_CP032519:182731-183132 [Cupriavidus oxalaticus]
ATGCAATGCCCAGTCTGCGGTGGCGCCAAGCTCGAGAGGCGCCGTAAGGATTTCGTATACACATACCGGGGTGAGTCCAC
AGTTTTCGAAGCCGTGCTTGCCGATTGGTGCCCGAAGTGCGGGGAAGGAGTCCTGGATGCGGAAGAAGAAGAGCGGATCG
GGCCACTCGCGCTTGCGTTCAACAAACAGGTCAATGCGTCGCTGATAGACCCGGCATACATTACCGGGGTACGCAAGAAA
CTTCGCCTGGACCAGCGCGAGGCGGCCGAGATCTTTGGAGGCGGCGTCAATGCATTCTCGCGCTACGAGACCGGCAAGAC
CAAGCCCCCGCTCGCGCTGGTCAAACTGCTGAAGCTGCTCGACCGCCACCCGGAACTGCTCGAAGAAGTCCGGGCAGCCT
GA

Structures

Antitoxin

• AlphaFold DB: A0A375FUY7