Detailed information of TA system TA111916

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symER/SymE(toxin)
• Location: 5129090..5129502
• Replicon: chromosome
• Accession: NZ_CP032515
• Organism: Escherichia coli strain 118UI

Toxin (Protein)

• Gene name: symE
• Uniprot ID: U9YSY7
• Locus tag: Eco118UI_RS25630
• Protein ID: WP_000132601.1
• Coordinates: 5129090..5129431 (-)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	symR
Locus tag	-
Coordinates	5129426..5129502 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Eco118UI_RS25620	5126503..5127549	-	1047	WP_000437621.1	5-methylcytosine-specific restriction endonuclease system specificity protein McrC	-
Eco118UI_RS25625	5127549..5128928	-	1380	WP_000443951.1	5-methylcytosine-specific restriction endonuclease subunit McrB	-
Eco118UI_RS25630	5129090..5129431	-	342	WP_000132601.1	endoribonuclease SymE	Toxin
-	5129426..5129502	+	77	NuclAT_10	-	Antitoxin
-	5129426..5129502	+	77	NuclAT_10	-	Antitoxin
-	5129426..5129502	+	77	NuclAT_10	-	Antitoxin
-	5129426..5129502	+	77	NuclAT_10	-	Antitoxin
-	5129426..5129502	+	77	NuclAT_11	-	Antitoxin
-	5129426..5129502	+	77	NuclAT_11	-	Antitoxin
-	5129426..5129502	+	77	NuclAT_11	-	Antitoxin
-	5129426..5129502	+	77	NuclAT_11	-	Antitoxin
Eco118UI_RS25635	5129659..5131053	-	1395	WP_001272445.1	type I restriction-modification system specificity subunit	-
Eco118UI_RS25640	5131050..5132639	-	1590	WP_001063200.1	type I restriction-modification system methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	5115486..5131053	15567

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12203.02 Da
• Isoelectric Point: 8.5012

>T111916 WP_000132601.1 NZ_CP032515:c5129431-5129090 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRHVTVGYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQAFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T111916 NZ_CP032515:c5129431-5129090 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCATGTCACCGTCGGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CTGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAGGAGAGCGAA
CTGATGCAGTCGCTACGCCAGGTGTGCAAACTGTCGGCGCGTAAACAAAAGCAGGTGCAGGCGTTTATTGGAGTGATTGC
CGGTAAACAGAAAGTCGCGTAA

Antitoxin

Nucleotide

• Length: 77 bp

>AT111916 NZ_CP032515:5129426-5129502 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: U9YSY7

Antitoxin