111910

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3647653..3648346 Replicon chromosome
Accession NZ_CP032515
Organism Escherichia coli strain 118UI

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag Eco118UI_RS18275 Protein ID WP_000415584.1
Coordinates 3648050..3648346 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag Eco118UI_RS18270 Protein ID WP_000650107.1
Coordinates 3647653..3648048 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Eco118UI_RS18260 3643517..3645775 - 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
Eco118UI_RS18265 3645913..3647520 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
Eco118UI_RS18270 3647653..3648048 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
Eco118UI_RS18275 3648050..3648346 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
Eco118UI_RS18280 3648551..3649033 - 483 WP_000183505.1 transcriptional regulator -
Eco118UI_RS18285 3649086..3649478 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
Eco118UI_RS18290 3649630..3650289 + 660 WP_001221493.1 two-component system response regulator QseB -
Eco118UI_RS18295 3650286..3651635 + 1350 WP_000673402.1 two-component system sensor histidine kinase QseC -
Eco118UI_RS18300 3651681..3652013 - 333 WP_000917684.1 DUF2645 family protein -
Eco118UI_RS18305 3652341..3652922 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
Eco118UI_RS18310 3652953..3653267 + 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T111910 WP_000415584.1 NZ_CP032515:c3648346-3648050 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T111910 NZ_CP032515:c3648346-3648050 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT111910 WP_000650107.1 NZ_CP032515:c3648048-3647653 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT111910 NZ_CP032515:c3648048-3647653 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LU65

References