Detailed information of TA system TA111879

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1735907..1736132
• Replicon: chromosome
• Accession: NZ_CP032513
• Organism: Shigella flexneri strain SFL1520

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: D6T62_RS09415
• Protein ID: WP_000813254.1
• Coordinates: 1735907..1736062 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	1736074..1736132 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D6T62_RS09380	1731167..1731532	+	366	WP_000124125.1	hypothetical protein	-
D6T62_RS09385	1731532..1732719	+	1188	Protein_1785	IS91 family transposase	-
D6T62_RS09390	1733130..1733684	-	555	WP_000640143.1	DUF1133 family protein	-
D6T62_RS09395	1733681..1733971	-	291	WP_000228038.1	DUF1364 domain-containing protein	-
D6T62_RS09400	1733971..1734570	-	600	WP_000940329.1	DUF1367 family protein	-
D6T62_RS09405	1734704..1735401	+	698	WP_237160603.1	IS1 family transposase	-
D6T62_RS09415	1735907..1736062	-	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
-	1736074..1736132	+	59	-	-	Antitoxin
D6T62_RS09420	1736517..1736882	-	366	WP_000610655.1	DUF551 domain-containing protein	-
D6T62_RS24445	1736882..1737547	-	666	WP_005115317.1	hypothetical protein	-
D6T62_RS09430	1737547..1737909	-	363	Protein_1793	HNH endonuclease	-
D6T62_RS09435	1737911..1738129	-	219	WP_000256997.1	DUF4014 family protein	-
D6T62_RS09440	1738222..1738578	-	357	WP_000403784.1	hypothetical protein	-
D6T62_RS09445	1738636..1739058	-	423	WP_001118171.1	DUF977 family protein	-
D6T62_RS09450	1739073..1739819	-	747	WP_000788996.1	ATP-binding protein	-
D6T62_RS24450	1739965..1740134	-	170	Protein_1798	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	sitABCD	-	1700669..1758991	58322

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T111879 WP_000813254.1 NZ_CP032513:c1736062-1735907 [Shigella flexneri]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T111879 NZ_CP032513:c1736062-1735907 [Shigella flexneri]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT111879 NZ_CP032513:1736074-1736132 [Shigella flexneri]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATTTGTGAGACATAGATTGGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin