Detailed information of TA system TA111859

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HTH_XRE
• Location: 22222..22933
• Replicon: plasmid pSO21_75
• Accession: NZ_CP032497
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium strain SO21

Toxin (Protein)

• Gene name: higB
• Uniprot ID: I2UJZ0
• Locus tag: D5069_RS24335
• Protein ID: WP_000162415.1
• Coordinates: 22631..22933 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: D5069_RS24330
• Protein ID: WP_000806445.1
• Coordinates: 22222..22560 (-)
• Length: 113 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D5069_RS24300	17294..18205	-	912	WP_024144056.1	hypothetical protein	-
D5069_RS24305	18473..19126	+	654	WP_001557715.1	hypothetical protein	-
D5069_RS24310	19455..19784	+	330	WP_000542383.1	hypothetical protein	-
D5069_RS24315	19777..20973	+	1197	WP_022630904.1	hypothetical protein	-
D5069_RS24795	21007..21744	-	738	WP_022630905.1	hypothetical protein	-
D5069_RS24325	21806..22165	-	360	WP_022630906.1	transcriptional regulator	-
D5069_RS24330	22222..22560	-	339	WP_000806445.1	HigA family addiction module antidote protein	Antitoxin
D5069_RS24335	22631..22933	-	303	WP_000162415.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
D5069_RS24340	23096..23887	+	792	WP_001557712.1	hypothetical protein	-
D5069_RS24345	23884..24651	+	768	WP_000203293.1	hypothetical protein	-
D5069_RS24350	24655..25635	+	981	WP_000046500.1	hypothetical protein	-
D5069_RS24355	25632..26285	+	654	WP_000828868.1	hypothetical protein	-
D5069_RS24360	26345..27250	+	906	WP_001258018.1	recombination-associated protein RdgC	-
D5069_RS24365	27234..27914	+	681	WP_000812238.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..74729	74729

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-111)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-42)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 14882.85 Da
• Isoelectric Point: 5.5500

>T111859 WP_000162415.1 NZ_CP032497:c22933-22631 [Salmonella enterica subsp. enterica serovar Typhimurium]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 303 bp

>T111859 NZ_CP032497:c22933-22631 [Salmonella enterica subsp. enterica serovar Typhimurium]
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Antitoxin

Protein

• Length: 113 a.a.
• Molecular weight: 16648.97 Da
• Isoelectric Point: 5.5500

>AT111859 WP_000806445.1 NZ_CP032497:c22560-22222 [Salmonella enterica subsp. enterica serovar Typhimurium]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 339 bp

>AT111859 NZ_CP032497:c22560-22222 [Salmonella enterica subsp. enterica serovar Typhimurium]
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Structures

Toxin

• AlphaFold DB: A0A631VBQ3