Detailed information of TA system TA111855

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HTH_XRE
• Location: 67375..68087
• Replicon: plasmid pSL26_91
• Accession: NZ_CP032492
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium strain SL26

Toxin (Protein)

• Gene name: higB
• Uniprot ID: I2UJZ0
• Locus tag: D5068_RS24790
• Protein ID: WP_000162415.1
• Coordinates: 67375..67677 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: D5068_RS24795
• Protein ID: WP_000806445.1
• Coordinates: 67749..68087 (+)
• Length: 113 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D5068_RS24760	62394..63074	-	681	WP_000812238.1	hypothetical protein	-
D5068_RS24765	63058..63963	-	906	WP_001258018.1	recombination-associated protein RdgC	-
D5068_RS24770	64023..64676	-	654	WP_000828868.1	hypothetical protein	-
D5068_RS24775	64673..65653	-	981	WP_000046500.1	hypothetical protein	-
D5068_RS24780	65657..66424	-	768	WP_000203295.1	hypothetical protein	-
D5068_RS24785	66421..67212	-	792	WP_153260509.1	phage tail protein	-
D5068_RS24790	67375..67677	+	303	WP_000162415.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
D5068_RS24795	67749..68087	+	339	WP_000806445.1	HigA family addiction module antidote protein	Antitoxin
D5068_RS24800	68144..68503	+	360	WP_044868318.1	transcriptional regulator	-
D5068_RS24805	68566..69294	+	729	WP_044868320.1	hypothetical protein	-
D5068_RS24810	69328..70521	-	1194	WP_153260510.1	phage tail protein	-
D5068_RS24815	70514..70843	-	330	WP_000542383.1	hypothetical protein	-
D5068_RS24820	71172..71825	-	654	WP_001557715.1	hypothetical protein	-
D5068_RS24825	72108..72716	+	609	WP_000776955.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..90686	90686

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (36-272)

Antitoxin

• AbiEi antitoxin C-terminal domain (84-237)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 12963.60 Da
• Isoelectric Point: 12.8000

>T111855 WP_000162415.1 NZ_CP032492:67375-67677 [Salmonella enterica subsp. enterica serovar Typhimurium]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 303 bp

>T111855 NZ_CP032492:67375-67677 [Salmonella enterica subsp. enterica serovar Typhimurium]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 113 a.a.
• Molecular weight: 14501.69 Da
• Isoelectric Point: 12.8492

>AT111855 WP_000806445.1 NZ_CP032492:67749-68087 [Salmonella enterica subsp. enterica serovar Typhimurium]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 339 bp

>AT111855 NZ_CP032492:67749-68087 [Salmonella enterica subsp. enterica serovar Typhimurium]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAA

Structures

Toxin

• AlphaFold DB: A0A631VBQ3