Detailed information of TA system TA111835

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1856879..1857059
• Replicon: chromosome
• Accession: NZ_CP032481
• Organism: Staphylococcus aureus strain O326

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: SaO326_RS09245
• Protein ID: WP_001801861.1
• Coordinates: 1856879..1856974 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1857002..1857059 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SaO326_RS09205	1851946..1852518	+	573	WP_000414229.1	hypothetical protein	-
SaO326_RS09210	1852894..1853730	+	837	WP_000190484.1	ABC transporter ATP-binding protein	-
SaO326_RS09220	1854537..1854722	-	186	WP_000809858.1	hypothetical protein	-
SaO326_RS09225	1854724..1854900	-	177	WP_000375476.1	hypothetical protein	-
SaO326_RS09230	1854911..1855294	-	384	WP_000070811.1	hypothetical protein	-
SaO326_RS09235	1855981..1856427	-	447	WP_000747809.1	DUF1433 domain-containing protein	-
SaO326_RS09245	1856879..1856974	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1857002..1857059	-	58	-	-	Antitoxin
SaO326_RS09250	1857097..1857198	+	102	WP_001791232.1	hypothetical protein	-
SaO326_RS09255	1857236..1857352	-	117	Protein_1738	transposase	-
SaO326_RS09260	1857861..1861973	-	4113	WP_000831220.1	ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (7-103)

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T111835 WP_001801861.1 NZ_CP032481:1856879-1856974 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T111835 NZ_CP032481:1856879-1856974 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin

Nucleotide

• Length: 58 bp

>AT111835 NZ_CP032481:c1857059-1857002 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin