111824

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ(toxin)
Location 1578642..1579230 Replicon chromosome
Accession NZ_CP032477
Organism Helicobacter pylori strain 169-C-EK8

Toxin (Protein)


Gene name TfiT Uniprot ID J0Q628
Locus tag D4K17_RS07795 Protein ID WP_000921930.1
Coordinates 1578642..1578923 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name TfiA Uniprot ID E8QSE8
Locus tag D4K17_RS07800 Protein ID WP_000065294.1
Coordinates 1578916..1579230 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D4K17_RS07760 1573842..1574105 + 264 WP_139522298.1 hypothetical protein -
D4K17_RS07765 1574102..1574401 + 300 WP_001942121.1 hypothetical protein -
D4K17_RS07770 1574401..1575342 + 942 WP_000625142.1 Flp pilus assembly complex ATPase component TadA -
D4K17_RS07775 1575339..1575794 + 456 WP_139522299.1 mobilization protein -
D4K17_RS07780 1575791..1576081 + 291 WP_078286910.1 hypothetical protein -
D4K17_RS07785 1576082..1576639 + 558 WP_139522300.1 hypothetical protein -
D4K17_RS07790 1576640..1578358 + 1719 WP_201737391.1 type IV secretory system conjugative DNA transfer family protein -
D4K17_RS07795 1578642..1578923 - 282 WP_000921930.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
D4K17_RS07800 1578916..1579230 - 315 WP_000065294.1 hypothetical protein Antitoxin
D4K17_RS07805 1579526..1581436 + 1911 WP_139522301.1 relaxase/mobilization nuclease domain-containing protein -
D4K17_RS07810 1581461..1582645 - 1185 WP_139522302.1 hypothetical protein -
D4K17_RS07815 1582689..1582973 - 285 WP_000394635.1 hypothetical protein -
D4K17_RS07820 1583055..1583711 - 657 WP_139522303.1 ParA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10932.85 Da        Isoelectric Point: 9.5726

>T111824 WP_000921930.1 NZ_CP032477:c1578923-1578642 [Helicobacter pylori]
MLKVRTKKDFLKDFNKHILSGRITENDVTSIVDCLKEQKPLQQKYCDHALSGNLKGLRECHVKPNLLLIYEIKKQENELV
LLRLDTHSELFKK

Download         Length: 282 bp

>T111824 NZ_CP032477:c1578923-1578642 [Helicobacter pylori]
ATGCTTAAAGTCAGAACTAAGAAAGATTTTCTTAAAGACTTTAATAAGCATATTTTATCTGGGCGTATTACAGAAAACGA
TGTTACAAGCATTGTTGATTGTCTCAAAGAGCAAAAACCACTCCAACAAAAATATTGCGACCATGCCTTGAGCGGCAATC
TTAAAGGGCTGAGAGAATGCCATGTCAAACCAAACTTGTTATTGATTTATGAAATCAAAAAACAAGAAAACGAACTTGTT
TTATTGCGTCTAGACACTCATAGCGAGCTATTTAAAAAGTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12166.60 Da        Isoelectric Point: 5.2068

>AT111824 WP_000065294.1 NZ_CP032477:c1579230-1578916 [Helicobacter pylori]
MSNIITDYSQYNEKQLHNFLNSIEKQLLKAEGDKNKAIKKIQECELQEQMIRQVLAQKHSQEKEPTPSLLNTIASKDDPE
YDVSFGDFNDFLQIAKQERERHNA

Download         Length: 315 bp

>AT111824 NZ_CP032477:c1579230-1578916 [Helicobacter pylori]
ATGTCAAATATTATTACAGATTACTCGCAATACAATGAAAAGCAACTGCATAATTTCTTAAACTCCATTGAAAAACAATT
GCTTAAGGCAGAAGGGGATAAAAATAAAGCGATAAAAAAAATCCAAGAGTGTGAATTGCAAGAACAAATGATCAGACAGG
TTTTAGCCCAAAAACATTCCCAAGAGAAAGAACCCACACCAAGTTTGTTAAATACGATCGCTTCAAAAGATGACCCAGAA
TACGATGTTTCGTTTGGAGACTTCAATGATTTTTTACAAATAGCAAAACAAGAAAGAGAAAGACATAATGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A6TF30

Antitoxin

Source ID Structure
AlphaFold DB A0A2T6R0U3

References