Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
| Location | 63797..64454 | Replicon | plasmid pSDU2-USMARC-69840 |
| Accession | NZ_CP032448 | ||
| Organism | Salmonella enterica subsp. enterica serovar Dublin strain USMARC-69840 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | U3PDC3 |
| Locus tag | DZA57_RS25660 | Protein ID | WP_000270043.1 |
| Coordinates | 63797..64147 (+) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | DZA57_RS25665 | Protein ID | WP_000124640.1 |
| Coordinates | 64152..64454 (+) | Length | 101 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| DZA57_RS25605 | 59108..59287 | + | 180 | Protein_74 | helix-turn-helix transcriptional regulator | - |
| DZA57_RS25610 | 59352..60056 | + | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| DZA57_RS25620 | 60271..60768 | - | 498 | WP_000062185.1 | hypothetical protein | - |
| DZA57_RS25625 | 60771..61259 | - | 489 | WP_001273096.1 | DUF1643 domain-containing protein | - |
| DZA57_RS25630 | 61356..61691 | + | 336 | WP_000683476.1 | hypothetical protein | - |
| DZA57_RS25635 | 61706..62176 | - | 471 | WP_001281821.1 | hypothetical protein | - |
| DZA57_RS25640 | 62169..62540 | - | 372 | WP_000516916.1 | hypothetical protein | - |
| DZA57_RS25645 | 62551..62745 | - | 195 | WP_000343597.1 | hypothetical protein | - |
| DZA57_RS25960 | 62773..62964 | + | 192 | WP_014342197.1 | hypothetical protein | - |
| DZA57_RS25655 | 63086..63634 | - | 549 | WP_001061574.1 | transcriptional regulator | - |
| DZA57_RS25660 | 63797..64147 | + | 351 | WP_000270043.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| DZA57_RS25665 | 64152..64454 | + | 303 | WP_000124640.1 | XRE family transcriptional regulator | Antitoxin |
| DZA57_RS25670 | 64481..64774 | - | 294 | WP_001239997.1 | chromosome segregation protein ParM | - |
| DZA57_RS25675 | 64862..65134 | - | 273 | WP_001043047.1 | HU family DNA-binding protein | - |
| DZA57_RS25680 | 65192..65719 | - | 528 | WP_001236377.1 | thermonuclease family protein | - |
| DZA57_RS25685 | 65736..65882 | - | 147 | WP_014342196.1 | hypothetical protein | - |
| DZA57_RS25690 | 65950..66807 | - | 858 | WP_001167032.1 | hypothetical protein | - |
| DZA57_RS25695 | 66794..67024 | - | 231 | WP_000972663.1 | hypothetical protein | - |
| DZA57_RS25700 | 67024..67542 | - | 519 | WP_000210756.1 | nitrite reductase | - |
| DZA57_RS25705 | 67539..67985 | - | 447 | WP_000919345.1 | Fe3+-siderophore ABC transporter permease | - |
| DZA57_RS25710 | 67985..68344 | - | 360 | WP_000422768.1 | hypothetical protein | - |
| DZA57_RS25715 | 68401..68829 | - | 429 | WP_000591074.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..77171 | 77171 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 15014.38 Da Isoelectric Point: 12.8644
>T111801 WP_000270043.1 NZ_CP032448:63797-64147 [Salmonella enterica subsp. enterica serovar Dublin]
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Download Length: 351 bp
>T111801 NZ_CP032448:63797-64147 [Salmonella enterica subsp. enterica serovar Dublin]
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Antitoxin
Download Length: 101 a.a. Molecular weight: 12963.60 Da Isoelectric Point: 12.8000
>AT111801 WP_000124640.1 NZ_CP032448:64152-64454 [Salmonella enterica subsp. enterica serovar Dublin]
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Download Length: 303 bp
>AT111801 NZ_CP032448:64152-64454 [Salmonella enterica subsp. enterica serovar Dublin]
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Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|