Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
| Location | 13140..13797 | Replicon | plasmid unnamed |
| Accession | NZ_CP032414 | ||
| Organism | Shewanella algae strain VGH117 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | U3PDC3 |
| Locus tag | D3X10_RS00100 | Protein ID | WP_000270043.1 |
| Coordinates | 13140..13490 (+) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | D3X10_RS00105 | Protein ID | WP_000124640.1 |
| Coordinates | 13495..13797 (+) | Length | 101 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| D3X10_RS00055 (D3X10_00055) | 8451..8630 | + | 180 | Protein_10 | helix-turn-helix domain-containing protein | - |
| D3X10_RS00060 (D3X10_00060) | 8695..9399 | + | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| D3X10_RS00065 (D3X10_00065) | 9614..10111 | - | 498 | WP_000062185.1 | hypothetical protein | - |
| D3X10_RS00070 (D3X10_00070) | 10114..10602 | - | 489 | WP_001273096.1 | DUF1643 domain-containing protein | - |
| D3X10_RS00075 (D3X10_00075) | 10699..11034 | + | 336 | WP_000683476.1 | hypothetical protein | - |
| D3X10_RS00080 (D3X10_00080) | 11049..11519 | - | 471 | WP_001281821.1 | hypothetical protein | - |
| D3X10_RS00085 (D3X10_00085) | 11512..11883 | - | 372 | WP_000516916.1 | hypothetical protein | - |
| D3X10_RS00090 (D3X10_00090) | 11894..12088 | - | 195 | WP_000343597.1 | hypothetical protein | - |
| D3X10_RS00095 (D3X10_00100) | 12429..12977 | - | 549 | WP_001061574.1 | transcriptional regulator | - |
| D3X10_RS00100 (D3X10_00105) | 13140..13490 | + | 351 | WP_000270043.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| D3X10_RS00105 (D3X10_00110) | 13495..13797 | + | 303 | WP_000124640.1 | XRE family transcriptional regulator | Antitoxin |
| D3X10_RS00110 (D3X10_00115) | 13824..14117 | - | 294 | WP_001239997.1 | chromosome segregation protein ParM | - |
| D3X10_RS00115 (D3X10_00120) | 14205..14477 | - | 273 | WP_001043047.1 | HU family DNA-binding protein | - |
| D3X10_RS00120 (D3X10_00125) | 14535..15062 | - | 528 | WP_001236377.1 | thermonuclease family protein | - |
| D3X10_RS00125 (D3X10_00135) | 15293..16150 | - | 858 | WP_001167032.1 | hypothetical protein | - |
| D3X10_RS00130 (D3X10_00140) | 16137..16367 | - | 231 | WP_000972663.1 | hypothetical protein | - |
| D3X10_RS00135 (D3X10_00145) | 16367..16885 | - | 519 | WP_000210756.1 | nitrite reductase | - |
| D3X10_RS00140 (D3X10_00150) | 16882..17328 | - | 447 | WP_000919345.1 | Fe3+-siderophore ABC transporter permease | - |
| D3X10_RS00145 (D3X10_00155) | 17328..17687 | - | 360 | WP_000422768.1 | hypothetical protein | - |
| D3X10_RS00150 (D3X10_00160) | 17744..18172 | - | 429 | WP_000591074.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | tet(A) / floR / sul2 / aph(3'')-Ib / aph(6)-Id | - | 1..132551 | 132551 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 13328.21 Da Isoelectric Point: 5.2421
>T111759 WP_000270043.1 NZ_CP032414:13140-13490 [Shewanella algae]
MWVIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPIRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE
MWVIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPIRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE
Download Length: 351 bp
>T111759 NZ_CP032414:13140-13490 [Shewanella algae]
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA
Antitoxin
Download Length: 101 a.a. Molecular weight: 11006.73 Da Isoelectric Point: 7.2036
>AT111759 WP_000124640.1 NZ_CP032414:13495-13797 [Shewanella algae]
MARTLDQMLATEKPEVVAKAQKAATEMLLNIHLAELRDRMNLTQGEIAASLGVRQPTVSEMEKPGRDLKLSSIKRYVEAS
GGKLRLDVELPDGTHYGFAV
MARTLDQMLATEKPEVVAKAQKAATEMLLNIHLAELRDRMNLTQGEIAASLGVRQPTVSEMEKPGRDLKLSSIKRYVEAS
GGKLRLDVELPDGTHYGFAV
Download Length: 303 bp
>AT111759 NZ_CP032414:13495-13797 [Shewanella algae]
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|