111750

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2456743..2457344 Replicon chromosome
Accession NZ_CP032405
Organism Rhizobium rosettiformans strain MAE2-X

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag D4A92_RS11790 Protein ID WP_203013285.1
Coordinates 2456743..2457024 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag D4A92_RS11795 Protein ID WP_203013288.1
Coordinates 2457039..2457344 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D4A92_RS11775 2452815..2453366 + 552 WP_203013275.1 LemA family protein -
D4A92_RS11780 2453491..2454756 + 1266 WP_203013278.1 3-phosphoshikimate 1-carboxyvinyltransferase -
D4A92_RS11785 2454753..2456690 + 1938 WP_203013282.1 DUF2207 domain-containing protein -
D4A92_RS11790 2456743..2457024 + 282 WP_203013285.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
D4A92_RS11795 2457039..2457344 + 306 WP_203013288.1 HigA family addiction module antidote protein Antitoxin
D4A92_RS11800 2457442..2459775 + 2334 WP_203013291.1 glycine--tRNA ligase subunit beta -
D4A92_RS11805 2459881..2460126 + 246 WP_203013294.1 type II toxin-antitoxin system ParD family antitoxin -
D4A92_RS11810 2460123..2460425 + 303 WP_203013296.1 type II toxin-antitoxin system RelE/ParE family toxin -
D4A92_RS11815 2460435..2460917 + 483 WP_203019930.1 DUF523 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(15-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-68)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10265.76 Da        Isoelectric Point: 7.8641

>T111750 WP_203013285.1 NZ_CP032405:2456743-2457024 [Rhizobium rosettiformans]
MIRSYASAMTEAVASGKAPKGFPADLLRRAVVKLTLIDNATSLTDLMRPPGNRLEALKGDRAGQHSIRINDQWRICFVWS
DNGAEQVEIVDCH

Download         Length: 282 bp

>T111750 NZ_CP032405:2456743-2457024 [Rhizobium rosettiformans]
ATGATCCGGTCTTATGCGAGTGCAATGACGGAGGCGGTGGCCTCTGGAAAAGCGCCTAAGGGCTTCCCCGCAGATCTTCT
TAGGCGTGCAGTCGTCAAGTTGACACTGATCGACAATGCCACCTCCCTGACAGATCTGATGCGCCCACCCGGCAACCGGT
TGGAAGCTTTGAAGGGCGACAGGGCTGGGCAACATTCGATCCGGATCAACGACCAATGGCGTATCTGCTTCGTCTGGTCC
GACAACGGTGCCGAACAGGTTGAGATCGTCGACTGCCACTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11267.05 Da        Isoelectric Point: 5.0644

>AT111750 WP_203013288.1 NZ_CP032405:2457039-2457344 [Rhizobium rosettiformans]
MTIVLPPVHPGEILRDEFLEPLNMSAGALARLLNVPRTRIERLVAEQTSLTPDTALRLARYFDMSPQFWMNLQTSYDLKT
EATAKAAELATIPVRTDLTAA

Download         Length: 306 bp

>AT111750 NZ_CP032405:2457039-2457344 [Rhizobium rosettiformans]
ATGACCATCGTCCTGCCGCCCGTCCATCCCGGTGAAATTCTGCGCGACGAATTCCTTGAGCCGCTGAACATGAGCGCTGG
CGCCCTTGCGCGCCTCTTGAACGTGCCGCGCACCCGGATTGAGCGTCTTGTCGCAGAGCAGACGTCGTTGACGCCCGATA
CGGCTCTGCGCCTTGCCCGCTATTTCGATATGTCGCCTCAGTTCTGGATGAACCTTCAGACCAGCTACGACCTGAAGACG
GAAGCGACGGCGAAAGCCGCCGAGCTGGCAACCATTCCGGTGCGAACAGATCTGACCGCCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References