Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1631..2288 Replicon plasmid p22453_1
Accession NZ_CP032395
Organism Salmonella enterica subsp. enterica serovar Dublin strain CVM 22453

Toxin (Protein)


Gene name higB Uniprot ID U3PDC3
Locus tag D5G00_RS25215 Protein ID WP_000270043.1
Coordinates 1631..1981 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag D5G00_RS25220 Protein ID WP_000124640.1
Coordinates 1986..2288 (+) Length 101 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D5G00_RS25195 3..374 - 372 WP_000516916.1 hypothetical protein -
D5G00_RS25200 385..579 - 195 WP_000343597.1 hypothetical protein -
D5G00_RS25210 920..1468 - 549 WP_001061574.1 transcriptional regulator -
D5G00_RS25215 1631..1981 + 351 WP_000270043.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
D5G00_RS25220 1986..2288 + 303 WP_000124640.1 XRE family transcriptional regulator Antitoxin
D5G00_RS25225 2315..2608 - 294 WP_001239997.1 chromosome segregation protein ParM -
D5G00_RS25230 2696..2968 - 273 WP_001043047.1 HU family DNA-binding protein -
D5G00_RS25235 3026..3553 - 528 WP_001236377.1 thermonuclease family protein -
D5G00_RS25245 3784..4641 - 858 WP_001167032.1 hypothetical protein -
D5G00_RS25250 4628..4858 - 231 WP_000972663.1 hypothetical protein -
D5G00_RS25255 4858..5376 - 519 WP_000210756.1 nitrite reductase -
D5G00_RS25260 5373..5819 - 447 WP_000919345.1 Fe3+-siderophore ABC transporter permease -
D5G00_RS25265 5819..6178 - 360 Protein_12 hypothetical protein -
D5G00_RS25270 6235..6663 - 429 WP_000591074.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..164900 164900


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-112)

Antitoxin

(5-38)


Sequences


Toxin        


Download         Length: 117 a.a.        Molecular weight: 15014.38 Da        Isoelectric Point: 12.8644

>T111733 WP_000270043.1 NZ_CP032395:1631-1981 [Salmonella enterica subsp. enterica serovar Dublin]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 351 bp

>T111733 NZ_CP032395:1631-1981 [Salmonella enterica subsp. enterica serovar Dublin]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 12963.60 Da        Isoelectric Point: 12.8000

>AT111733 WP_000124640.1 NZ_CP032395:1986-2288 [Salmonella enterica subsp. enterica serovar Dublin]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKK

Download         Length: 303 bp

>AT111733 NZ_CP032395:1986-2288 [Salmonella enterica subsp. enterica serovar Dublin]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A7G8AFB9


Antitoxin

Source ID Structure

References