Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
| Location | 127349..128006 | Replicon | plasmid p34981_1 |
| Accession | NZ_CP032391 | ||
| Organism | Salmonella enterica subsp. enterica serovar Dublin strain CVM 34981 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | U3PDC3 |
| Locus tag | D5F99_RS25565 | Protein ID | WP_000270043.1 |
| Coordinates | 127656..128006 (-) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | D5F99_RS25560 | Protein ID | WP_000124640.1 |
| Coordinates | 127349..127651 (-) | Length | 101 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| D5F99_RS25510 | 122974..123402 | + | 429 | WP_000591074.1 | hypothetical protein | - |
| D5F99_RS25515 | 123459..123818 | + | 360 | WP_000422768.1 | hypothetical protein | - |
| D5F99_RS25520 | 123818..124264 | + | 447 | WP_000919345.1 | Fe3+-siderophore ABC transporter permease | - |
| D5F99_RS25525 | 124261..124779 | + | 519 | WP_000210756.1 | nitrite reductase | - |
| D5F99_RS25530 | 124779..125009 | + | 231 | WP_000972663.1 | hypothetical protein | - |
| D5F99_RS25535 | 124996..125853 | + | 858 | WP_001167032.1 | hypothetical protein | - |
| D5F99_RS25545 | 126084..126611 | + | 528 | WP_001236377.1 | thermonuclease family protein | - |
| D5F99_RS25550 | 126669..126941 | + | 273 | WP_001043047.1 | HU family DNA-binding protein | - |
| D5F99_RS25555 | 127029..127322 | + | 294 | WP_001239997.1 | chromosome segregation protein ParM | - |
| D5F99_RS25560 | 127349..127651 | - | 303 | WP_000124640.1 | XRE family transcriptional regulator | Antitoxin |
| D5F99_RS25565 | 127656..128006 | - | 351 | WP_000270043.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| D5F99_RS25570 | 128169..128717 | + | 549 | WP_001061574.1 | transcriptional regulator | - |
| D5F99_RS25580 | 129058..129252 | + | 195 | WP_000343597.1 | hypothetical protein | - |
| D5F99_RS25585 | 129263..129634 | + | 372 | WP_000516916.1 | hypothetical protein | - |
| D5F99_RS25590 | 129627..130097 | + | 471 | WP_001281821.1 | hypothetical protein | - |
| D5F99_RS25595 | 130112..130447 | - | 336 | WP_000683476.1 | hypothetical protein | - |
| D5F99_RS25600 | 130544..131032 | + | 489 | WP_001273096.1 | DUF1643 domain-containing protein | - |
| D5F99_RS25605 | 131035..131532 | + | 498 | WP_000062185.1 | hypothetical protein | - |
| D5F99_RS25610 | 131747..132451 | - | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| D5F99_RS25615 | 132516..132695 | - | 180 | Protein_155 | helix-turn-helix transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..146176 | 146176 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 17237.68 Da Isoelectric Point: 5.5500
>T111726 WP_000270043.1 NZ_CP032391:c128006-127656 [Salmonella enterica subsp. enterica serovar Dublin]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
Download Length: 351 bp
>T111726 NZ_CP032391:c128006-127656 [Salmonella enterica subsp. enterica serovar Dublin]
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Antitoxin
Download Length: 101 a.a. Molecular weight: 14882.85 Da Isoelectric Point: 5.5500
>AT111726 WP_000124640.1 NZ_CP032391:c127651-127349 [Salmonella enterica subsp. enterica serovar Dublin]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
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Download Length: 303 bp
>AT111726 NZ_CP032391:c127651-127349 [Salmonella enterica subsp. enterica serovar Dublin]
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Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|