Detailed information of TA system TA111655

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 2949457..2949952
• Replicon: chromosome
• Accession: NZ_CP032329
• Organism: Xenorhabdus nematophila strain YL001

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: D3790_RS13065
• Protein ID: WP_081480213.1
• Coordinates: 2949457..2949651 (+)
• Length: 65 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: D3790_RS13070
• Protein ID: WP_010848973.1
• Coordinates: 2949653..2949952 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D3790_RS13035	2944814..2945155	-	342	WP_013183347.1	hypothetical protein	-
D3790_RS13040	2945164..2945872	+	709	Protein_2505	transposase	-
D3790_RS13045	2946076..2946849	+	774	WP_010848977.1	amino acid ABC transporter substrate-binding protein	-
D3790_RS13050	2947133..2947849	+	717	WP_010848976.1	amino acid ABC transporter permease	-
D3790_RS13055	2947827..2948591	+	765	WP_010848975.1	amino acid ABC transporter ATP-binding protein	-
D3790_RS13060	2948645..2949433	+	789	WP_010848974.1	amino acid ABC transporter substrate-binding protein	-
D3790_RS13065	2949457..2949651	+	195	WP_081480213.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
D3790_RS13070	2949653..2949952	+	300	WP_010848973.1	XRE family transcriptional regulator	Antitoxin
D3790_RS13075	2950075..2950347	-	273	WP_081990835.1	hypothetical protein	-
D3790_RS13080	2950380..2951345	-	966	WP_010848971.1	PDR/VanB family oxidoreductase	-
D3790_RS13085	2951524..2952666	-	1143	WP_010847875.1	transposase	-
D3790_RS13090	2952723..2953151	+	429	WP_038218908.1	IS200/IS605 family transposase	-
D3790_RS13095	2953202..2954635	-	1434	WP_013183340.1	NAD-dependent succinate-semialdehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-55)

Antitoxin

• Cro/C1-type helix-turn-helix domain (31-80)

Sequences

Toxin

Protein

• Length: 65 a.a.
• Molecular weight: 7507.59 Da
• Isoelectric Point: 8.5012

>T111655 WP_081480213.1 NZ_CP032329:2949457-2949651 [Xenorhabdus nematophila]
IDYISIDCSLYTRTIRAFFAFDPERQAVVFCAGNKAGKNQKSFYRDMIKVADEQFRIHLNNLEK

Nucleotide

• Length: 195 bp

>T111655 NZ_CP032329:2949457-2949651 [Xenorhabdus nematophila]
ATAGACTACATATCTATAGATTGTAGTCTATATACTCGAACAATCCGGGCATTTTTTGCATTTGATCCAGAACGTCAGGC
TGTTGTTTTTTGCGCAGGAAATAAAGCAGGGAAAAACCAAAAGTCATTCTATCGGGATATGATTAAGGTTGCTGACGAAC
AATTCAGAATCCATCTAAACAATTTGGAGAAATGA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 10868.74 Da
• Isoelectric Point: 8.4812

>AT111655 WP_010848973.1 NZ_CP032329:2949653-2949952 [Xenorhabdus nematophila]
MATLKELMAKRSPESQAKIEEKAAEMLLETQLYQIREALALSQTQVAKNLGIAQSSVAAIEQRGNELKISTLKKYIEAMG
GEMTLGVKLPDGKLMNFSI

Nucleotide

• Length: 300 bp

>AT111655 NZ_CP032329:2949653-2949952 [Xenorhabdus nematophila]
ATGGCTACTTTAAAAGAACTGATGGCAAAACGTAGCCCAGAAAGTCAAGCCAAAATAGAAGAAAAAGCAGCCGAAATGTT
GCTTGAAACGCAACTATACCAAATTCGTGAAGCATTAGCCCTTTCACAAACTCAGGTAGCAAAAAACCTGGGTATAGCCC
AATCATCAGTTGCAGCTATTGAACAACGAGGAAATGAATTGAAAATTTCCACACTGAAAAAATACATTGAAGCGATGGGC
GGCGAAATGACTTTGGGAGTCAAATTACCTGATGGAAAATTAATGAATTTCTCCATTTAA