Detailed information of TA system TA111360

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-orzP/Ldr(toxin)
• Location: 3591257..3591478
• Replicon: chromosome
• Accession: NZ_CP032204
• Organism: Escherichia coli strain AR_0013

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: A0A229AEQ8
• Locus tag: AM340_RS18095
• Protein ID: WP_000176713.1
• Coordinates: 3591257..3591364 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	orzP
Locus tag	-
Coordinates	3591412..3591478 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AM340_RS18070	3587101..3588183	+	1083	WP_000804726.1	peptide chain release factor 1	-
AM340_RS18075	3588183..3589016	+	834	WP_000456446.1	peptide chain release factor N(5)-glutamine methyltransferase	-
AM340_RS18080	3589013..3589405	+	393	WP_000200374.1	invasion regulator SirB2	-
AM340_RS18085	3589409..3590218	+	810	WP_001257044.1	invasion regulator SirB1	-
AM340_RS18090	3590254..3591108	+	855	WP_000811065.1	3-deoxy-8-phosphooctulonate synthase	-
AM340_RS18095	3591257..3591364	-	108	WP_000176713.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	3591412..3591478	+	67	NuclAT_13	-	Antitoxin
-	3591412..3591478	+	67	NuclAT_13	-	Antitoxin
-	3591412..3591478	+	67	NuclAT_13	-	Antitoxin
-	3591412..3591478	+	67	NuclAT_13	-	Antitoxin
-	3591412..3591478	+	67	NuclAT_15	-	Antitoxin
-	3591412..3591478	+	67	NuclAT_15	-	Antitoxin
-	3591412..3591478	+	67	NuclAT_15	-	Antitoxin
-	3591412..3591478	+	67	NuclAT_15	-	Antitoxin
-	3591412..3591478	+	67	NuclAT_17	-	Antitoxin
-	3591412..3591478	+	67	NuclAT_17	-	Antitoxin
-	3591412..3591478	+	67	NuclAT_17	-	Antitoxin
-	3591412..3591478	+	67	NuclAT_17	-	Antitoxin
-	3591412..3591478	+	67	NuclAT_19	-	Antitoxin
-	3591412..3591478	+	67	NuclAT_19	-	Antitoxin
-	3591412..3591478	+	67	NuclAT_19	-	Antitoxin
-	3591412..3591478	+	67	NuclAT_19	-	Antitoxin
-	3591412..3591478	+	67	NuclAT_21	-	Antitoxin
-	3591412..3591478	+	67	NuclAT_21	-	Antitoxin
-	3591412..3591478	+	67	NuclAT_21	-	Antitoxin
-	3591412..3591478	+	67	NuclAT_21	-	Antitoxin
-	3591412..3591478	+	67	NuclAT_23	-	Antitoxin
-	3591412..3591478	+	67	NuclAT_23	-	Antitoxin
-	3591412..3591478	+	67	NuclAT_23	-	Antitoxin
-	3591412..3591478	+	67	NuclAT_23	-	Antitoxin
-	3591414..3591477	+	64	NuclAT_46	-	-
-	3591414..3591477	+	64	NuclAT_46	-	-
-	3591414..3591477	+	64	NuclAT_46	-	-
-	3591414..3591477	+	64	NuclAT_46	-	-
-	3591414..3591477	+	64	NuclAT_48	-	-
-	3591414..3591477	+	64	NuclAT_48	-	-
-	3591414..3591477	+	64	NuclAT_48	-	-
-	3591414..3591477	+	64	NuclAT_48	-	-
AM340_RS18100	3591792..3591899	-	108	WP_000170956.1	type I toxin-antitoxin system toxin Ldr family protein	-
-	3591952..3592013	+	62	NuclAT_45	-	-
-	3591952..3592013	+	62	NuclAT_45	-	-
-	3591952..3592013	+	62	NuclAT_45	-	-
-	3591952..3592013	+	62	NuclAT_45	-	-
-	3591952..3592013	+	62	NuclAT_47	-	-
-	3591952..3592013	+	62	NuclAT_47	-	-
-	3591952..3592013	+	62	NuclAT_47	-	-
-	3591952..3592013	+	62	NuclAT_47	-	-
-	3591952..3592014	+	63	NuclAT_14	-	-
-	3591952..3592014	+	63	NuclAT_14	-	-
-	3591952..3592014	+	63	NuclAT_14	-	-
-	3591952..3592014	+	63	NuclAT_14	-	-
-	3591952..3592014	+	63	NuclAT_16	-	-
-	3591952..3592014	+	63	NuclAT_16	-	-
-	3591952..3592014	+	63	NuclAT_16	-	-
-	3591952..3592014	+	63	NuclAT_16	-	-
-	3591952..3592014	+	63	NuclAT_18	-	-
-	3591952..3592014	+	63	NuclAT_18	-	-
-	3591952..3592014	+	63	NuclAT_18	-	-
-	3591952..3592014	+	63	NuclAT_18	-	-
-	3591952..3592014	+	63	NuclAT_20	-	-
-	3591952..3592014	+	63	NuclAT_20	-	-
-	3591952..3592014	+	63	NuclAT_20	-	-
-	3591952..3592014	+	63	NuclAT_20	-	-
-	3591952..3592014	+	63	NuclAT_22	-	-
-	3591952..3592014	+	63	NuclAT_22	-	-
-	3591952..3592014	+	63	NuclAT_22	-	-
-	3591952..3592014	+	63	NuclAT_22	-	-
-	3591952..3592014	+	63	NuclAT_24	-	-
-	3591952..3592014	+	63	NuclAT_24	-	-
-	3591952..3592014	+	63	NuclAT_24	-	-
-	3591952..3592014	+	63	NuclAT_24	-	-
AM340_RS18105	3592305..3593405	-	1101	WP_001317783.1	sodium-potassium/proton antiporter ChaA	-
AM340_RS18110	3593675..3593905	+	231	WP_001146444.1	putative cation transport regulator ChaB	-
AM340_RS18115	3594063..3594758	+	696	WP_015674647.1	glutathione-specific gamma-glutamylcyclotransferase	-
AM340_RS18120	3594802..3595155	-	354	WP_001169669.1	DsrE/F sulfur relay family protein YchN	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4031.79 Da
• Isoelectric Point: 11.4779

>T111360 WP_000176713.1 NZ_CP032204:c3591364-3591257 [Escherichia coli]
MTLTQFAMTFWHDLAAPILAGIITAAIVSWWRNRK

Nucleotide

• Length: 108 bp

>T111360 NZ_CP032204:c3591364-3591257 [Escherichia coli]
ATGACGCTCACGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Nucleotide

• Length: 67 bp

>AT111360 NZ_CP032204:3591412-3591478 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• AlphaFold DB: A0A229AEQ8

Antitoxin