Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 85573..86300 Replicon plasmid unnamed1
Accession NZ_CP032164
Organism Klebsiella pneumoniae strain XJ-K1

Toxin (Protein)


Gene name higB Uniprot ID A0A7W3D9W1
Locus tag D3H40_RS27750 Protein ID WP_011251285.1
Coordinates 85573..85884 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag D3H40_RS27755 Protein ID WP_011251286.1
Coordinates 85881..86300 (+) Length 140 a.a.

Genomic Context

D3H40_RS27705D3H40_RS27710D3H40_RS27745D3H40_RS27750D3H40_RS27755D3H40_RS27765D3H40_RS30695D3H40_RS27790D3H40_RS27720D3H40_RS27725D3H40_RS27730D3H40_RS27735D3H40_RS27740D3H40_RS27770D3H40_RS27775D3H40_RS27780
Location: 80584..81094 (511 bp)
Type: Others
Protein ID: Protein_90
Location: 81084..81524 (441 bp)
Type: Others
Protein ID: WP_011251275.1
Location: 84910..85368 (459 bp)
Type: Others
Protein ID: Protein_97
Location: 85573..85884 (312 bp)
Type: Toxin
Protein ID: WP_011251285.1
Location: 85881..86300 (420 bp)
Type: Antitoxin
Protein ID: WP_011251286.1
Location: 86447..87415 (969 bp)
Type: Others
Protein ID: WP_074428168.1
Location: 89714..90469 (756 bp)
Type: Others
Protein ID: Protein_104
Location: 90662..91132 (471 bp)
Type: Others
Protein ID: WP_048333570.1
Location: 81949..82905 (957 bp)
Type: Others
Protein ID: WP_011251280.1
Location: 82965..83306 (342 bp)
Type: Others
Protein ID: WP_011251281.1
Location: 83320..83631 (312 bp)
Type: Others
Protein ID: WP_011251282.1
Location: 83648..84082 (435 bp)
Type: Others
Protein ID: Protein_95
Location: 84099..84796 (698 bp)
Type: Others
Protein ID: Protein_96
Location: 87517..87852 (336 bp)
Type: Others
Protein ID: Protein_101
Location: 87866..88654 (789 bp)
Type: Others
Protein ID: WP_040217257.1
Location: 88675..89118 (444 bp)
Type: Others
Protein ID: WP_048333569.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
D3H40_RS2770580584..81094+511Protein_90hypothetical protein-
D3H40_RS2771081084..81524+441WP_011251275.1hypothetical protein-
D3H40_RS2772081949..82905-957WP_011251280.1DsbA family protein-
D3H40_RS2772582965..83306-342WP_011251281.1hypothetical protein-
D3H40_RS2773083320..83631-312WP_011251282.1hypothetical protein-
D3H40_RS2773583648..84082-435Protein_95thioredoxin fold domain-containing protein-
D3H40_RS2774084099..84796-698Protein_96IS1 family transposase-
D3H40_RS2774584910..85368+459Protein_97DDE-type integrase/transposase/recombinase-
D3H40_RS2775085573..85884+312WP_011251285.1type II toxin-antitoxin system HigB family toxinToxin
D3H40_RS2775585881..86300+420WP_011251286.1helix-turn-helix domain-containing proteinAntitoxin
D3H40_RS2776586447..87415+969WP_074428168.1IS5 family transposase-
D3H40_RS2777087517..87852-336Protein_101conjugal transfer protein TraI-
D3H40_RS2777587866..88654-789WP_040217257.1hypothetical protein-
D3H40_RS2778088675..89118-444WP_048333569.1hypothetical protein-
D3H40_RS3069589714..90469+756Protein_104hypothetical protein-
D3H40_RS2779090662..91132+471WP_048333570.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideMobilizable plasmid-rmpA2 / iutA / iucD / iucC / iucB / iucA1..207409207409
-insideIScluster/Tn--78664..10297124307


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(22-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(85-138)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12346.12 Da        Isoelectric Point: 9.7248

>T111199 WP_011251285.1 NZ_CP032164:85573-85884 [Klebsiella pneumoniae]
MHVISKEPFEEAAKRYPNDSLAIRALYRLVRETDFSSPAEMLTLIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFVNKRF
YVKHIATHADYDKLTRYYRENKE

Download         Length: 312 bp

>T111199 NZ_CP032164:85573-85884 [Klebsiella pneumoniae]
ATGCACGTAATTTCAAAAGAGCCTTTTGAGGAAGCGGCAAAGCGATATCCCAACGATTCGTTAGCCATTCGGGCGTTGTA
CCGCTTAGTGCGCGAGACGGACTTCTCTTCTCCAGCTGAGATGCTAACTCTGATACCGAGCCTGGATAATTTTAAGTACA
GGAATAAGTGGTGGGTTTTGGATGTAGGGGGCAACAACTTAAGGGTTATCGCCTATATCAATTTCGTAAATAAGCGCTTC
TACGTGAAGCACATCGCAACCCACGCTGATTACGACAAGTTGACCCGCTATTACAGGGAGAACAAAGAATGA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15377.46 Da        Isoelectric Point: 4.4420

>AT111199 WP_011251286.1 NZ_CP032164:85881-86300 [Klebsiella pneumoniae]
MITDTAKAIEATKQLVAAVPFLGGSSSESDYREAMELVDYLIENDDENPLIDFLASKIADYEDNSPRFAEFNKAIAEIPV
GVALLRTLIDQHKLSYSDLKDEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPEWFL

Download         Length: 420 bp

>AT111199 NZ_CP032164:85881-86300 [Klebsiella pneumoniae]
ATGATTACCGACACTGCAAAAGCCATTGAAGCAACCAAACAACTCGTAGCTGCCGTCCCCTTCCTAGGGGGCAGTTCTTC
CGAGAGCGATTACCGCGAAGCGATGGAGCTGGTGGATTATCTGATCGAGAACGACGACGAGAACCCACTTATTGACTTCC
TGGCGAGTAAGATTGCCGACTATGAAGATAACAGCCCTCGTTTCGCTGAGTTCAACAAAGCTATTGCTGAAATACCAGTC
GGCGTTGCACTTCTGCGAACCCTGATTGACCAGCACAAGCTGTCTTATTCAGACCTTAAGGATGAGATCGGATCTAAATC
ATTGGTCAGCCAAATCCTGTCAGGGCAGCGCTCTTTGACCATCACTCACATAAAAGCTCTTTCCGCGCGCTTCGGTGTAA
AACCTGAGTGGTTCCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A7W3D9W1

Antitoxin

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Source
ID
Structure
No matching records found

References