Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 356317..356963 Replicon chromosome
Accession NZ_CP032163
Organism Klebsiella pneumoniae strain XJ-K1

Toxin (Protein)


Gene name higB Uniprot ID W8UNE1
Locus tag D3H40_RS01665 Protein ID WP_002920560.1
Coordinates 356317..356664 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID W8UB68
Locus tag D3H40_RS01670 Protein ID WP_002920557.1
Coordinates 356664..356963 (+) Length 100 a.a.

Genomic Context

D3H40_RS01655D3H40_RS01660D3H40_RS01665D3H40_RS01670D3H40_RS01680D3H40_RS01685D3H40_RS01690D3H40_RS01675
Location: 352243..353676 (1434 bp)
Type: Others
Protein ID: WP_002920564.1
Location: 353694..356141 (2448 bp)
Type: Others
Protein ID: WP_002920561.1
Location: 356317..356664 (348 bp)
Type: Toxin
Protein ID: WP_002920560.1
Location: 356664..356963 (300 bp)
Type: Antitoxin
Protein ID: WP_002920557.1
Location: 358739..359068 (330 bp)
Type: Others
Protein ID: WP_002920552.1
Location: 359119..359949 (831 bp)
Type: Others
Protein ID: WP_004151408.1
Location: 359999..360757 (759 bp)
Type: Others
Protein ID: WP_002920548.1
Location: 357026..358534 (1509 bp)
Type: Others
Protein ID: WP_002920554.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
D3H40_RS01655352243..353676+1434WP_002920564.1glycogen synthase GlgA-
D3H40_RS01660353694..356141+2448WP_002920561.1glycogen phosphorylase-
D3H40_RS01665356317..356664+348WP_002920560.1type II toxin-antitoxin system RelE/ParE family toxinToxin
D3H40_RS01670356664..356963+300WP_002920557.1helix-turn-helix transcriptional regulatorAntitoxin
D3H40_RS01675357026..358534-1509WP_002920554.1glycerol-3-phosphate dehydrogenase-
D3H40_RS01680358739..359068+330WP_002920552.1thiosulfate sulfurtransferase GlpE-
D3H40_RS01685359119..359949+831WP_004151408.1rhomboid family intramembrane serine protease GlpG-
D3H40_RS01690359999..360757+759WP_002920548.1DeoR/GlpR family transcriptional regulator-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13502.56 Da        Isoelectric Point: 6.2300

>T111181 WP_002920560.1 NZ_CP032163:356317-356664 [Klebsiella pneumoniae]
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRACFAFDPLRKAI
VLCVGNKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

>T111181 NZ_CP032163:356317-356664 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTGTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGTGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10800.58 Da        Isoelectric Point: 10.1464

>AT111181 WP_002920557.1 NZ_CP032163:356664-356963 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT111181 NZ_CP032163:356664-356963 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0E1CBY5

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0E1CBF8

References