Detailed information of TA system TA111172

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 52004..52514
• Replicon: chromosome
• Accession: NZ_CP032159
• Organism: Staphylococcus warneri strain 22.1

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: D3P10_RS00365
• Protein ID: WP_049416776.1
• Coordinates: 52251..52514 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: D3P10_RS00360
• Protein ID: WP_049416774.1
• Coordinates: 52004..52258 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D3P10_RS00345	47512..48834	+	1323	WP_049416769.1	PrsW family intramembrane metalloprotease	-
D3P10_RS00350	48985..49422	+	438	WP_002466379.1	hypothetical protein	-
D3P10_RS00355	49549..51759	-	2211	WP_049416771.1	YSIRK-type signal peptide-containing protein	-
D3P10_RS00360	52004..52258	+	255	WP_049416774.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
D3P10_RS00365	52251..52514	+	264	WP_049416776.1	Txe/YoeB family addiction module toxin	Toxin
D3P10_RS00370	52672..54120	-	1449	WP_049416778.1	aldehyde dehydrogenase family protein	-
D3P10_RS00375	54282..55391	+	1110	WP_050969455.1	NAD(P)-dependent alcohol dehydrogenase	-
D3P10_RS00380	55696..57066	+	1371	WP_049416781.1	citrate:proton symporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10414.10 Da
• Isoelectric Point: 9.8163

>T111172 WP_049416776.1 NZ_CP032159:52251-52514 [Staphylococcus warneri]
MSRLNILFTPDAFEDYKYWQIHDKKLLKKINHLIKCINRNGPLEGEGKPEALKGNFKGYYSRRINFEHRLVYKVHDSEII
IVSCKYQ

Nucleotide

• Length: 264 bp

>T111172 NZ_CP032159:52251-52514 [Staphylococcus warneri]
ATGAGTAGATTAAATATTTTATTTACACCTGATGCATTTGAAGATTATAAATATTGGCAAATTCATGATAAAAAATTATT
AAAAAAGATTAACCATTTAATAAAATGTATAAATCGTAATGGCCCACTCGAAGGTGAAGGAAAACCTGAAGCTTTGAAAG
GTAATTTTAAGGGATATTATAGTAGAAGAATCAATTTTGAACATAGGTTAGTTTATAAAGTACATGATTCAGAAATAATT
ATTGTTTCTTGTAAATATCAGTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9373.33 Da
• Isoelectric Point: 4.0334

>AT111172 WP_049416774.1 NZ_CP032159:52004-52258 [Staphylococcus warneri]
MAIVSYSIARKNFRSLIDKVNNDSDAVTITTNDSNAVLISESDYNAMMETLYLQQSPANAQHLAKSIEDVERGNTIEVDL
ESYE

Nucleotide

• Length: 255 bp

>AT111172 NZ_CP032159:52004-52258 [Staphylococcus warneri]
ATGGCAATAGTATCGTACTCAATAGCTAGAAAAAATTTTAGAAGTTTAATAGATAAAGTTAACAATGATTCAGATGCGGT
GACTATAACAACTAATGATAGCAATGCTGTACTGATTTCGGAGTCAGATTACAATGCGATGATGGAGACATTATACCTCC
AACAATCCCCTGCTAATGCGCAACACTTGGCTAAATCTATAGAAGATGTTGAGCGTGGAAATACAATAGAGGTAGATTTA
GAATCATATGAGTAG