Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 1842769..1843387 Replicon chromosome
Accession NZ_CP032125
Organism Profundibacter amoris strain BAR1

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag BAR1_RS09155 Protein ID WP_118942740.1
Coordinates 1843103..1843387 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag BAR1_RS09150 Protein ID WP_118942739.1
Coordinates 1842769..1843086 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BAR1_RS09145 1839348..1842536 - 3189 WP_118944412.1 AAA family ATPase -
BAR1_RS09150 1842769..1843086 - 318 WP_118942739.1 HigA family addiction module antidote protein Antitoxin
BAR1_RS09155 1843103..1843387 - 285 WP_118942740.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BAR1_RS09160 1844092..1845417 - 1326 WP_118942741.1 hypothetical protein -
BAR1_RS09165 1845595..1845984 + 390 WP_162891729.1 hypothetical protein -
BAR1_RS09170 1845984..1846982 + 999 WP_118942743.1 hypothetical protein -
BAR1_RS09175 1846979..1847668 + 690 WP_118942744.1 hypothetical protein -
BAR1_RS09180 1847684..1848040 + 357 WP_118942745.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1804515..1853192 48677


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-94)

Antitoxin

Cro/C1-type helix-turn-helix domain

(9-66)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10600.94 Da        Isoelectric Point: 8.9764

>T111112 WP_118942740.1 NZ_CP032125:c1843387-1843103 [Profundibacter amoris]
MIQGYRDKKTENFAGGKFVKSFQGFEAQAAKRLAILNAAPALDTLQALPSNRLEALRGDRSGQYSIRINQQWRICFEWSE
GQPGPSNVEIVDYH

Download         Length: 285 bp

>T111112 NZ_CP032125:c1843387-1843103 [Profundibacter amoris]
ATGATACAGGGCTATCGAGACAAAAAGACTGAAAATTTTGCAGGCGGTAAGTTCGTAAAATCGTTCCAGGGGTTTGAAGC
CCAGGCTGCAAAGCGACTGGCGATCCTGAACGCGGCTCCTGCACTCGATACCTTGCAAGCATTACCAAGCAACAGATTGG
AAGCGCTACGCGGGGACAGGTCGGGGCAGTATTCCATTCGCATCAATCAGCAATGGCGTATTTGTTTCGAATGGTCAGAA
GGCCAACCTGGACCATCAAATGTTGAAATCGTGGACTACCATTAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11841.57 Da        Isoelectric Point: 6.4669

>AT111112 WP_118942739.1 NZ_CP032125:c1843086-1842769 [Profundibacter amoris]
MYMRTVHPGVILKDELEEIGITPTEFARQIDVPPNRVSQIISGKRSVTGDTALRFGHWFDTDPQFWINLQAQYELAVAGK
ETGDVIKRLPTKATLPPQAEQPRLV

Download         Length: 318 bp

>AT111112 NZ_CP032125:c1843086-1842769 [Profundibacter amoris]
ATGTATATGAGAACTGTTCATCCCGGCGTTATCCTTAAGGACGAGCTGGAAGAAATAGGCATCACGCCGACCGAGTTTGC
ACGCCAGATCGACGTGCCACCCAACCGCGTCAGCCAGATTATTTCTGGCAAGCGCAGCGTAACAGGCGACACCGCGCTTC
GGTTCGGGCACTGGTTTGACACTGATCCGCAGTTTTGGATCAATCTACAGGCGCAGTATGAGCTTGCCGTAGCGGGCAAA
GAAACCGGTGATGTTATCAAGCGCTTGCCGACAAAGGCGACCTTACCGCCTCAAGCAGAGCAGCCAAGGTTAGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References