Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
Location | 20465..21111 | Replicon | plasmid pL25922_3 |
Accession | NZ_CP032086 | ||
Organism | Escherichia coli strain ATCC 25922 |
Toxin (Protein)
Gene name | higB | Uniprot ID | A0A7R6ZH56 |
Locus tag | D1792_RS24770 | Protein ID | WP_000269913.1 |
Coordinates | 20764..21111 (-) | Length | 116 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | A0A1V3UZT0 |
Locus tag | D1792_RS24765 | Protein ID | WP_001259436.1 |
Coordinates | 20465..20764 (-) | Length | 100 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
D1792_RS24735 | 16300..16872 | - | 573 | WP_000137931.1 | helix-turn-helix transcriptional regulator | - |
D1792_RS24740 | 17446..17637 | + | 192 | WP_000183352.1 | hypothetical protein | - |
D1792_RS24745 | 17634..18776 | + | 1143 | WP_000854799.1 | ORF6N domain-containing protein | - |
D1792_RS24750 | 18787..18975 | - | 189 | WP_000986262.1 | hypothetical protein | - |
D1792_RS24755 | 19585..19857 | - | 273 | WP_000148349.1 | helix-turn-helix domain-containing protein | - |
D1792_RS24760 | 19921..20301 | - | 381 | WP_000061764.1 | hypothetical protein | - |
D1792_RS24765 | 20465..20764 | - | 300 | WP_001259436.1 | XRE family transcriptional regulator | Antitoxin |
D1792_RS24770 | 20764..21111 | - | 348 | WP_000269913.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
D1792_RS24775 | 21356..21619 | - | 264 | WP_000424604.1 | hypothetical protein | - |
D1792_RS24780 | 21643..21930 | - | 288 | WP_000356589.1 | hypothetical protein | - |
D1792_RS24785 | 22574..23410 | - | 837 | WP_001139598.1 | hypothetical protein | - |
D1792_RS24790 | 23736..24290 | - | 555 | WP_001199265.1 | recombinase family protein | - |
D1792_RS24795 | 24456..25382 | + | 927 | Protein_37 | phage tail protein | - |
D1792_RS24800 | 25384..25911 | + | 528 | WP_000972103.1 | tail fiber assembly protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | - | - | 1..94204 | 94204 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 116 a.a. Molecular weight: 13486.53 Da Isoelectric Point: 9.8723
>T111090 WP_000269913.1 NZ_CP032086:c21111-20764 [Escherichia coli]
MWTVLFSQRFDGWLNEQEDALQEKVLADLKKLQVYGPELPRPYADTVKGSRYKNMKELRVQFSGRPIRAFYAFDPIRRAI
VLCAGDKSNDKRFYKKLVRIAEDEFAAHLNTLESK
MWTVLFSQRFDGWLNEQEDALQEKVLADLKKLQVYGPELPRPYADTVKGSRYKNMKELRVQFSGRPIRAFYAFDPIRRAI
VLCAGDKSNDKRFYKKLVRIAEDEFAAHLNTLESK
Download Length: 348 bp
>T111090 NZ_CP032086:c21111-20764 [Escherichia coli]
ATGTGGACGGTACTTTTTAGCCAGCGATTTGACGGCTGGCTAAATGAGCAAGAAGACGCTCTTCAGGAAAAGGTTTTGGC
TGATTTGAAAAAGCTACAGGTTTACGGACCTGAGTTACCCAGGCCATATGCCGATACCGTAAAAGGTTCTCGGTACAAAA
ATATGAAAGAGCTTCGCGTTCAGTTTTCTGGCCGTCCGATAAGAGCCTTTTATGCGTTCGATCCGATTCGCCGGGCTATC
GTTCTTTGTGCAGGAGACAAAAGTAACGATAAGCGGTTTTATAAAAAACTGGTGCGTATAGCTGAGGATGAGTTTGCAGC
ACATCTGAACACACTGGAGAGCAAGTAA
ATGTGGACGGTACTTTTTAGCCAGCGATTTGACGGCTGGCTAAATGAGCAAGAAGACGCTCTTCAGGAAAAGGTTTTGGC
TGATTTGAAAAAGCTACAGGTTTACGGACCTGAGTTACCCAGGCCATATGCCGATACCGTAAAAGGTTCTCGGTACAAAA
ATATGAAAGAGCTTCGCGTTCAGTTTTCTGGCCGTCCGATAAGAGCCTTTTATGCGTTCGATCCGATTCGCCGGGCTATC
GTTCTTTGTGCAGGAGACAAAAGTAACGATAAGCGGTTTTATAAAAAACTGGTGCGTATAGCTGAGGATGAGTTTGCAGC
ACATCTGAACACACTGGAGAGCAAGTAA
Antitoxin
Download Length: 100 a.a. Molecular weight: 11074.92 Da Isoelectric Point: 5.2090
>AT111090 WP_001259436.1 NZ_CP032086:c20764-20465 [Escherichia coli]
MRTLDEVIASRSPESQARIKEMADEMILEVGLQMMREELQLSQKQVAEAMGISQPAVTKLEQRGNDLKLATLKRYVEAMG
GKLSLDVELPTGKRIAFNI
MRTLDEVIASRSPESQARIKEMADEMILEVGLQMMREELQLSQKQVAEAMGISQPAVTKLEQRGNDLKLATLKRYVEAMG
GKLSLDVELPTGKRIAFNI
Download Length: 300 bp
>AT111090 NZ_CP032086:c20764-20465 [Escherichia coli]
ATGAGAACATTAGATGAGGTGATTGCCAGCCGTTCACCGGAAAGCCAGGCGCGAATTAAAGAAATGGCAGATGAGATGAT
TCTTGAGGTCGGCTTGCAGATGATGCGTGAAGAACTCCAGTTATCACAAAAGCAGGTTGCTGAGGCGATGGGTATAAGCC
AGCCAGCAGTAACAAAGCTGGAGCAGCGCGGAAATGATTTAAAGCTGGCGACATTAAAGCGTTACGTTGAAGCTATGGGA
GGCAAATTAAGCCTGGATGTTGAGCTTCCCACAGGAAAACGAATAGCGTTTAACATCTGA
ATGAGAACATTAGATGAGGTGATTGCCAGCCGTTCACCGGAAAGCCAGGCGCGAATTAAAGAAATGGCAGATGAGATGAT
TCTTGAGGTCGGCTTGCAGATGATGCGTGAAGAACTCCAGTTATCACAAAAGCAGGTTGCTGAGGCGATGGGTATAAGCC
AGCCAGCAGTAACAAAGCTGGAGCAGCGCGGAAATGATTTAAAGCTGGCGACATTAAAGCGTTACGTTGAAGCTATGGGA
GGCAAATTAAGCCTGGATGTTGAGCTTCCCACAGGAAAACGAATAGCGTTTAACATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7R6ZH56 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1V3UZT0 |