Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 98450..98704 | Replicon | plasmid p.CT30-P2 |
| Accession | NZ_CP032080 | ||
| Organism | Escherichia coli strain CT30 | ||
Toxin (Protein)
| Gene name | srnB | Uniprot ID | G9G1E3 |
| Locus tag | D2195_RS25390 | Protein ID | WP_001312851.1 |
| Coordinates | 98450..98599 (-) | Length | 50 a.a. |
Antitoxin (RNA)
| Gene name | sok | ||
| Locus tag | - | ||
| Coordinates | 98643..98704 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| D2195_RS25360 (94780) | 94780..95067 | - | 288 | WP_000222766.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| D2195_RS25365 (95064) | 95064..95315 | - | 252 | WP_001132900.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| D2195_RS25370 (96278) | 96278..97135 | - | 858 | WP_000774297.1 | incFII family plasmid replication initiator RepA | - |
| D2195_RS25375 (97128) | 97128..97610 | - | 483 | WP_001273588.1 | hypothetical protein | - |
| D2195_RS26440 (97603) | 97603..97650 | - | 48 | WP_229471593.1 | hypothetical protein | - |
| D2195_RS26445 (97641) | 97641..97892 | + | 252 | WP_223195197.1 | replication protein RepA | - |
| D2195_RS25385 (97909) | 97909..98166 | - | 258 | WP_000083845.1 | replication regulatory protein RepA | - |
| D2195_RS25390 (98450) | 98450..98599 | - | 150 | WP_001312851.1 | Hok/Gef family protein | Toxin |
| - (98643) | 98643..98704 | + | 62 | NuclAT_1 | - | Antitoxin |
| - (98643) | 98643..98704 | + | 62 | NuclAT_1 | - | Antitoxin |
| - (98643) | 98643..98704 | + | 62 | NuclAT_1 | - | Antitoxin |
| - (98643) | 98643..98704 | + | 62 | NuclAT_1 | - | Antitoxin |
| D2195_RS25395 (98960) | 98960..99034 | - | 75 | Protein_114 | endonuclease | - |
| D2195_RS25400 (99280) | 99280..99492 | - | 213 | WP_001299730.1 | ANR family transcriptional regulator | - |
| D2195_RS25405 (99628) | 99628..100188 | - | 561 | WP_000139315.1 | fertility inhibition protein FinO | - |
| D2195_RS25410 (100291) | 100291..101151 | - | 861 | WP_000704513.1 | alpha/beta hydrolase | - |
| D2195_RS25415 (101210) | 101210..101956 | - | 747 | WP_000205749.1 | conjugal transfer pilus acetylase TraX | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | sitABCD | vat / iutA / iucD / iucC / iucB / iucA / iroN / iroE / iroD / iroC / iroB | 1..146245 | 146245 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 50 a.a. Molecular weight: 5542.67 Da Isoelectric Point: 8.7678
>T111050 WP_001312851.1 NZ_CP032080:c98599-98450 [Escherichia coli]
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK
Download Length: 150 bp
>T111050 NZ_CP032080:c98599-98450 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA
Antitoxin
Download Length: 62 bp
>AT111050 NZ_CP032080:98643-98704 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
