Detailed information of TA system TA111016

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 272167..272389
• Replicon: chromosome
• Accession: NZ_CP032078
• Organism: Escherichia coli strain CT30

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: A0A829L523
• Locus tag: D2195_RS01295
• Protein ID: WP_000170738.1
• Coordinates: 272282..272389 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	272167..272233 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D2195_RS01275	267608..268510	+	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-
D2195_RS01280	268521..269504	+	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
D2195_RS01285	269501..270505	+	1005	WP_000107036.1	dipeptide ABC transporter ATP-binding subunit DppF	-
D2195_RS01290	270535..271806	-	1272	WP_001318103.1	aromatic amino acid transport family protein	-
-	272167..272233	-	67	-	-	Antitoxin
D2195_RS01295	272282..272389	+	108	WP_000170738.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
D2195_RS01300	272765..272872	+	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	-
D2195_RS01305	273248..273355	+	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	-
D2195_RS01310	273731..273838	+	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	-
D2195_RS01315	273925..275604	-	1680	WP_001562264.1	cellulose biosynthesis protein BcsG	-
D2195_RS01320	275601..275792	-	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
D2195_RS01325	275789..277360	-	1572	WP_001204944.1	cellulose biosynthesis c-di-GMP-binding protein BcsE	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3864.67 Da
• Isoelectric Point: 9.0157

>T111016 WP_000170738.1 NZ_CP032078:272282-272389 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASLIVNWLNKRK

Nucleotide

• Length: 108 bp

>T111016 NZ_CP032078:272282-272389 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATAGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 67 bp

>AT111016 NZ_CP032078:c272233-272167 [Escherichia coli]
GTCTAGGTTCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• AlphaFold DB: A0A829L523

Antitoxin