Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 1011241..1011934 Replicon chromosome
Accession NZ_CP032073
Organism Escherichia coli strain CT29

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag D2194_RS04880 Protein ID WP_000415584.1
Coordinates 1011638..1011934 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag D2194_RS04875 Protein ID WP_000650107.1
Coordinates 1011241..1011636 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D2194_RS04865 (1007105) 1007105..1009363 - 2259 WP_001281841.1 DNA topoisomerase IV subunit A -
D2194_RS04870 (1009501) 1009501..1011108 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
D2194_RS04875 (1011241) 1011241..1011636 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
D2194_RS04880 (1011638) 1011638..1011934 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
D2194_RS04885 (1012139) 1012139..1012621 - 483 WP_000183489.1 GyrI-like domain-containing protein -
D2194_RS04890 (1012674) 1012674..1013066 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
D2194_RS04895 (1013218) 1013218..1013877 + 660 WP_001221502.1 quorum sensing response regulator transcription factor QseB -
D2194_RS04900 (1013874) 1013874..1015223 + 1350 WP_000673357.1 quorum sensing histidine kinase QseC -
D2194_RS04905 (1015269) 1015269..1015580 - 312 WP_212403430.1 DUF2645 family protein -
D2194_RS04910 (1015694) 1015694..1016674 - 981 WP_000019450.1 IS5-like element ISKpn26 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1015694..1016674 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T110997 WP_000415584.1 NZ_CP032073:c1011934-1011638 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T110997 NZ_CP032073:c1011934-1011638 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT110997 WP_000650107.1 NZ_CP032073:c1011636-1011241 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT110997 NZ_CP032073:c1011636-1011241 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References