Detailed information of TA system TA110944

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2438881..2439398
• Replicon: chromosome
• Accession: NZ_CP032051
• Organism: Staphylococcus aureus strain O17

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: SaO17_RS12610
• Protein ID: WP_000375483.1
• Coordinates: 2438881..2439147 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YB60
• Locus tag: SaO17_RS12615
• Protein ID: WP_000584499.1
• Coordinates: 2439147..2439398 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SaO17_RS12585	2434032..2434568	-	537	WP_000185901.1	GNAT family N-acetyltransferase	-
SaO17_RS12590	2435088..2435912	-	825	WP_000594631.1	formate/nitrite transporter family protein	-
SaO17_RS12595	2436115..2436297	-	183	WP_000079140.1	hypothetical protein	-
SaO17_RS12600	2436384..2436851	-	468	WP_000153340.1	SRPBCC domain-containing protein	-
SaO17_RS12605	2437037..2438587	-	1551	WP_118848158.1	zinc ABC transporter substrate-binding lipoprotein AdcA	-
SaO17_RS12610	2438881..2439147	-	267	WP_000375483.1	Txe/YoeB family addiction module toxin	Toxin
SaO17_RS12615	2439147..2439398	-	252	WP_000584499.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
SaO17_RS12620	2439562..2439662	-	101	Protein_2346	hypothetical protein	-
SaO17_RS12625	2439669..2440268	-	600	WP_000162810.1	DsbA family protein	-
SaO17_RS12630	2440287..2440649	-	363	WP_000819843.1	DUF4467 domain-containing protein	-
SaO17_RS12635	2440904..2442154	+	1251	WP_001012239.1	FemA/FemB family glycyltransferase FmhA	-
SaO17_RS12640	2442247..2442978	-	732	WP_000615461.1	amino acid ABC transporter ATP-binding protein	-
SaO17_RS12645	2442975..2443694	-	720	WP_000479576.1	amino acid ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10450.05 Da
• Isoelectric Point: 10.2538

>T110944 WP_000375483.1 NZ_CP032051:c2439147-2438881 [Staphylococcus aureus]
MDRLNITFSPQAFADYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYKVDDNHIK
IASCKYHY

Nucleotide

• Length: 267 bp

>T110944 NZ_CP032051:c2439147-2438881 [Staphylococcus aureus]
ATGGATAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGCAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGCGCATTGAAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATAAAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9433.60 Da
• Isoelectric Point: 4.3407

>AT110944 WP_000584499.1 NZ_CP032051:c2439398-2439147 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Nucleotide

• Length: 252 bp

>AT110944 NZ_CP032051:c2439398-2439147 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAATCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Structures

Antitoxin

• AlphaFold DB: T1YB60